130032-63-2Relevant academic research and scientific papers
Imidazodiazepinediones: A New Class of Adenosine Receptor Antagonists
Daly, John W.,Hide, Izumi,Bridson, Peter K.
, p. 2818 - 2821 (1990)
A series of imidazodiazepine-5,8-diones were synthesized from hypoxanthines.Certain of these cyclic homologues of caffeine, theophylline theobromine, 3-isobutyl-1-methylxanthine, and enprophylline were inhibitors of binding of adenosine analogues to rat brain A1 and A2 adenosine receptors and were antagonists of A2 adenosine receptors stimulatory to adenylate cyclase in rat PC12 cell membranes.Activity at adenosine receptors was lower than the corresponding xanthines, perhaps because imidazodiazepinediones contain a boat-shaped seven-membered ring rather than the planar ring system of the xanthines.The imidazodiazepinediones had low affinity for brain benzodiazepine sites.
