130054-54-5

Basic information

• Product Name: 1-(3-Pyridinylmethyl)-3-piperidinol
• Synonyms: 1-(3-PYRIDINYLMETHYL)-3-PIPERIDINOL
• CAS NO: 130054-54-5
• Molecular Formula: C11H16N2O
• Molecular Weight: 192.26
• Mol File: 130054-54-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 323°C at 760 mmHg
• Flash Point: 149.2°C
• Appearance: /
• Density: 1.157g/cm³
• Vapor Pressure: 0.000111mmHg at 25°C
• Refractive Index: 1.582
• CAS DataBase Reference: 1-(3-Pyridinylmethyl)-3-piperidinol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-Pyridinylmethyl)-3-piperidinol(130054-54-5)
• EPA Substance Registry System: 1-(3-Pyridinylmethyl)-3-piperidinol(130054-54-5)

Safety Data

• Hazardous Substances Data: 130054-54-5(Hazardous Substances Data)

Usage

General Description

1-(3-Pyridinylmethyl)-3-piperidinol is a chemical compound that belongs to the organic class of compounds known as Piperidinols. It consists of a pyridine ring which is a simple aromatic ring with a nitrogen atom) and a piperidine ring (a type of organic compound with a saturated cyclohexane structure with one nitrogen atom). This chemical compound is used primarily in the pharmaceutical industry, and plays a important role as an intermediate in the synthesis of various drugs. It's a solid substance that is insoluble in water, and must be handled with care due to its potent nature. However, specifics about the compound's precise use, toxicity and safety measures aren't generally available publicly, highlighting the need to follow standard safety procedures while handling it.

InChI:InChI=1/C11H16N2O/c14-11-4-2-6-13(9-11)8-10-3-1-5-12-7-10/h1,3,5,7,11,14H,2,4,6,8-9H2

Upstream product

• 6859-99-0 3-hydroxypiperazine 

Downstream Products

• 130054-64-7 2-[1-(3-Nitro-phenyl)-meth-(E)-ylidene]-3-oxo-butyric acid 1-pyridin-3-ylmethyl-piperidin-3-yl ester 

Relevant articles and documents

Novel 2-amino-1,4-dihydropyridine calcium antagonists. II. Synthesis and antihypertensive effects of 2-amino-1,4-dihydropyridine derivatives having N,N-dialkylaminoalkoxycarbonyl groups at 3- and/or 5-positions

Novel 2-amino-1,4-dihydropyridine derivatives I, which contain N,N-dialkylaminoalkoxycarbonyl groups at the 3- and/or 5-position, were synthesized and their antihypertensive effects were evaluated in spontaneously hypertensive rats. Remarkably prolonged duration of antihypertensive action was observed when a tertiary amino group was introduced into either the 3- or 5-ester side-chain of the 1,4-dihydropyridine ring. In particular, the compounds containing cyclic amino moieties at the 3-position showed greater potency than those with acyclic amino moieties. Chemical modification studies indicated that the two ester side-chains of 1,4-dihydropyridine at the 3- and 5-position might function in a different manner in relation to the antihypertensive activities. 3-(1-Benzhydrylazetidin-3-yl) 5-isopropyl 2-amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxyl ate, I-43 (CS-905), exhibited potent and long-lasting antihypertensive effects with gradual onset of action, and is a promising candidate as an antihypertensive drug.