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1,2-(2'-Hydroxyl-4',4''-bis-alpha-pyranol)diphenylethanone is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 130064-21-0 Structure
  • Basic information

    1. Product Name: 1,2-(2'-Hydroxyl-4',4''-bis-alpha-pyranol)diphenylethanone
    2. Synonyms: 1,2-(2'-Hydroxyl-4',4''-bis-alpha-pyranol)diphenylethanone;1,2- (2''-HYDROXYL-4'',4''-BIS-A-PYRANOL)DIPHENYLETHANONE 99+%;1-[2-Hydroxy-4-[(tetrahydro-2H-pyran-2-yl)oxy]phenyl]-2-[4-[(tetrahydro-2H-pyran-2-yl)oxy]phenyl]ethanone;1-[2-hydroxy-4-(oxan-2-yloxy)phenyl]-2-[4-(oxan-2-yloxy)phenyl]ethanone
    3. CAS NO:130064-21-0
    4. Molecular Formula: C24H28O6
    5. Molecular Weight: 412.48
    6. EINECS: N/A
    7. Product Categories: API intermediates
    8. Mol File: 130064-21-0.mol
  • Chemical Properties

    1. Melting Point: 118 °C(Solv: hexane (110-54-3))
    2. Boiling Point: 613.291 °C at 760 mmHg
    3. Flash Point: 210.403 °C
    4. Appearance: /
    5. Density: 1.230
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C
    8. Solubility: N/A
    9. PKA: 7.34±0.35(Predicted)
    10. CAS DataBase Reference: 1,2-(2'-Hydroxyl-4',4''-bis-alpha-pyranol)diphenylethanone(CAS DataBase Reference)
    11. NIST Chemistry Reference: 1,2-(2'-Hydroxyl-4',4''-bis-alpha-pyranol)diphenylethanone(130064-21-0)
    12. EPA Substance Registry System: 1,2-(2'-Hydroxyl-4',4''-bis-alpha-pyranol)diphenylethanone(130064-21-0)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 130064-21-0(Hazardous Substances Data)

130064-21-0 Usage

Preparation

Preparation by reaction of 3,4-dihydro-2H-pyran with 1-(2,4-dihydroxyphenyl)-2- (4-hydroxyphenyl)ethanone in concentrated hydrochloric acid and stirring in an ice bath for 4 h (87%).

Check Digit Verification of cas no

The CAS Registry Mumber 130064-21-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,0,0,6 and 4 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 130064-21:
(8*1)+(7*3)+(6*0)+(5*0)+(4*6)+(3*4)+(2*2)+(1*1)=70
70 % 10 = 0
So 130064-21-0 is a valid CAS Registry Number.

130064-21-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-[2-hydroxy-4-(oxan-2-yloxy)phenyl]-2-[4-(oxan-2-yloxy)phenyl]ethanone

1.2 Other means of identification

Product number -
Other names 1-[2-hydroxy-4-(tetrahydropyran-2-yloxy)-phenyl]-2-[4-(tetrahydropyran-2-yloxy)-phenyl]-ethanone

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:130064-21-0 SDS

130064-21-0Relevant articles and documents

Identification of an Orally Bioavailable Chromene-Based Selective Estrogen Receptor Degrader (SERD) That Demonstrates Robust Activity in a Model of Tamoxifen-Resistant Breast Cancer

Nagasawa, Johnny,Govek, Steven,Kahraman, Mehmet,Lai, Andiliy,Bonnefous, Celine,Douglas, Karensa,Sensintaffar, John,Lu, Nhin,Lee, Kyoungjin,Aparicio, Anna,Kaufman, Josh,Qian, Jing,Shao, Gang,Prudente, Rene,Joseph, James D.,Darimont, Beatrice,Brigham, Daniel,Maheu, Kate,Heyman, Richard,Rix, Peter J.,Hager, Jeffrey H.,Smith, Nicholas D.

supporting information, p. 7917 - 7928 (2018/09/06)

About 75% of breast cancers are estrogen receptor alpha (ER-α) positive, and women typically initially respond well to antihormonal therapies such as tamoxifen and aromatase inhibitors, but resistance often emerges. Fulvestrant is a steroid-based, selective estrogen receptor degrader (SERD) that both antagonizes and degrades ER-α and shows some activity in patients who have progressed on antihormonal agents. However, fulvestrant must be administered by intramuscular injections that limit its efficacy. We describe the optimization of ER-α degradation efficacy of a chromene series of ER modulators resulting in highly potent and efficacious SERDs such as 14n. When examined in a xenograft model of tamoxifen-resistant breast cancer, 14n (ER-α degradation efficacy = 91%) demonstrated robust activity, while, despite superior oral exposure, 15g (ER-α degradation efficacy = 82%) was essentially inactive. This result suggests that optimizing ER-α degradation efficacy in the MCF-7 cell line leads to compounds with robust effects in models of tamoxifen-resistant breast cancer derived from an MCF-7 background.

TREATMENT OF HOT FLUSHES, VASOMOTOR SYMPTOMS, AND NIGHT SWEATS WITH SEX STEROID PRECURSORS IN COMBINATION WITH SELECTIVE ESTROGEN RECEPTOR MODULATORS

-

Paragraph 0143, (2017/08/01)

Novel methods for reduction or elimination of the incidence of hot flushes, vasomotor symptoms, and night sweats while decreasing the risk of acquiring breast, uterine or endometrial cancer and furthermore having beneficial effect by inhibiting the develo

TREATMENT OF MALE ANDROGEN DEFICIENCY SYMPTOMS OR DISEASES WITH SEX STEROID PRECURSOR COMBINED WITH SERM

-

Paragraph 0228; 0231, (2015/09/28)

Novel methods for prevention, reduction or elimination of the incidence of male androgen deficiency symptoms or diseases including male hypogonadism-associated symptoms and diseases associated with low serum testosterone and/or low DHEA or low total andro

COMBINATIONS OF BENZOPYRAN COMPOUNDS, COMPOSITIONS AND USES THEREOF

-

Paragraph 00196, (2015/01/07)

This invention relates to a method of treating a disorder modulated, mediated or affected by the estrogen receptor in a subject comprising administering to the subject a specific benzopyran (in the form of a mixture of S-C2 and R-C2 diastereomers or its pure S-diastereomer) in combination with an agent selected from the group consisting of an mTOR inhibitor, a CDK 4/6 inhibitor, a PI3 Kinase inhibitor, a taxane, an antimetabolite, and an antitumor antibiotic.

SUBSTITUTED BENZOPYRAN COMPOUNDS, COMPOSITIONS AND USES THEREOF

-

Paragraph 00105; 00107, (2015/01/07)

Benzopyran compounds with anti-estrogenic activity are provided as Formula I, II, III, IV, V, VI, VII, VIII, IX, X, XI, XII, XIII, XIV, XV, XVI, XVII and XVIII. These compounds are useful for the treatment or prevention of a variety of conditions that are modulated through the estrogen receptor in mammals including humans.

NOVEL BENZOPYRAN COMPOUNDS, COMPOSITIONS AND USES THEREOF

-

Paragraph 00149, (2013/07/05)

Benzopyran compounds with strong anti-estrogenic activity and essentially no estrogenic activity are provided, which are OP- 1038, which is 3-(4-hydroxyphenyl)-4-methyl-2-(4-{2-[(3R)-3-methylpyrrolidin-l-yl]ethoxy}phenyl)-2H-chromen-7-ol, and OP-1074, which is (2S)-3-(4-hydroxyphenyl)-4-methyl-2-(4-{2-[(3R)-3-methylpyrrolidin- 1 -yl]ethoxy}phenyl)-2H-chromen-7-ol. OP-1074 is a pure anti-estrogen when tested in the agonist mode and a complete anti-estrogen when tested in the antagonist mode. These compounds are useful for the treatment or prevention of a variety of conditions that are modulated through the estrogen receptor in mammals including humans.

Indazoles, benzisoxazoles and benzisothiazoles as estrogenic agents

-

Page/Page column 23-24, (2008/06/13)

The present invention relates to compounds of formula (I): in which R1, R2, R3, X, Y and A are as defined in the specification. The compounds are modulators of the estrogen receptors.

4-fluoroalkyl-2h-benzopyrans anti-estogenic activity

-

, (2008/06/13)

This invention describes the new 4-fluoroalkyl-2H-benzopyrans of general formula I, in which Z is a straight-chain or branched-chain alkyl group with up to 5 carbon atoms that is fluorinated in at least one place, preferably a trifluoromethyl group, and R1, R2, X, Y and n have the meanings that are indicated in the description. The new compounds have at their disposal strong antiestrogenic action. In addition, they can have at their disposal estrogenic action that occurs in a tissue-selective manner. They can be used for the production of pharmaceutical agents, especially for the treatment of estrogen-dependent diseases and tumors and pharmaceutical agents for hormone replacement therapy (HRT) as well as for the prevention and treatment of osteoporosis.

Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors

-

Page column 31; 34, (2008/06/13)

Novel methods for the medical treatment and/or inhibition of the development of osteoporosis, breast cancer, hypercholesterolemia, hyperlipidemia or atherosclerosis in susceptible warm-blooded animals including humans involving administration of selective

Benzopyran-containing compounds and prodrug forms thereof

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Page 13, (2008/06/13)

Certain benzopyran antiestrogens are disclosed for treating estrogen sensitive diseases such as breast cancer. Prodrug forms provide ease of manufacturing, good shelf life, and bioavailibility.

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