1300730-72-6

Upstream product

• 85-44-9 phthalic anhydride 
• 5339-85-5 2-aminophenethyl alcohol 

Downstream Products

• 481001-67-6 (-)-benzyl 1,2,3,4-tetrahydroquinoline-2-carboxylate 
• 481001-67-6 benzyl 1,2,3,4-tetrahydroquinoline-2-carboxylate 
• 63492-81-9 methyl (2R)-1,2,3,4-tetrahydroquinoline-2-carboxylate 
• 63430-79-5 1,2,3,4-tetrahydro-quinoline-2-carboxylic acid methyl ester 
• 63492-82-0 methyl (2S)-1,2,3,4-tetrahydroquinoline-2-carboxylate 

Relevant academic research and scientific papers

Enantioselective Copper-Catalyzed Intramolecular N?H Bond Insertion: Synthesis of Chiral 2-Carboxytetrahydroquinolines

The first highly enantioselective intramolecular N?H bond insertion was realized by using copper catalysts modified with chiral spirobisoxazoline ligands, which provides a novel strategy for the synthesis of chiral 2-carboxytetrahydroquinolines. This reaction features fast reaction rate, high yield, high enantioselectivity, and mild reaction conditions. (Figure presented.).

IMIDAZOLE DERIVATIVES AS IDO INHIBITORS

Presently provided are IDO inhibitors of general formulae (VII), (VIII) as shown below and pharmaceutical compositions thereof, useful for modulating an activity of indoleamine 2,3-dioxygenase; treating indoleamine 2,3-dioxygenase (IDO) mediated immunosuppression; treating a medical conditions that benefit from the inhibition of enzymatic activity of indoleamine-2,3-dioxygenase; enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent; treating tumor-specific immunosuppression associated with cancer; and treating immunosupression associated with an infectious disease.