130074-95-2Relevant academic research and scientific papers
Reactions of Epoxides Derived from 2'-(3"-Methylbut-2"-enyl)trifluoroacetanilides
Raner, Kevin D.,Skelton, Brian W.,Ward, A. David,White, Allan H.
, p. 609 - 616 (2007/10/02)
The intramolecular nucleophilic ring opening of the epoxides derived from 2'-(3"-methylbut-2"-enyl)trifluoroacetanilides has been investigated under both acidic and basic conditions.Boron trifluoride caused rearrangement of the epoxides to a ketone but no cyclization.Potassium carbonate in methanol caused regiospecific opening of the epoxides and generated dihydroindole products.The formation of a five-membered ring was confirmed by a single-crystal X-ray study of one of the products.The epoxides hydrolysed very readily in acidic conditions; the structure of one of the diol products was confirmed by a single-crystal X-ray study.
