13009-99-9

Basic information

• Product Name: Mafenide acetate
• Synonyms: 4-(aminomethyl)benzenesulfonamidemonoacetate;4-(aminomethyl)-benzenesulfonamidmonoacetate;alpha-amino-p-toluenesulfonamidmonoacetate;mafatate;maphenideacetate;MARFANIL;MARFANIL ACETATE SALT;MAFENAMIDE ACETATE
• CAS NO: 13009-99-9
• Molecular Formula: C₂H₄O₂*C₇H₁₀N₂O₂S
• Molecular Weight: 246.28
• EINECS: 235-855-0
• Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds
• Mol File: 13009-99-9.mol
• Article Data: 0

Chemical Properties

• Melting Point: 151-152°C
• Boiling Point: 382 °C at 760 mmHg
• Flash Point: 184.8 °C
• Appearance: white/
• Vapor Pressure: 4.86E-06mmHg at 25°C
• Storage Temp.: Refrigerator
• Solubility: DMSO: soluble1mg/mL
• CAS DataBase Reference: Mafenide acetate(CAS DataBase Reference)
• NIST Chemistry Reference: Mafenide acetate(13009-99-9)
• EPA Substance Registry System: Mafenide acetate(13009-99-9)

Safety Data

• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 13009-99-9(Hazardous Substances Data)

Usage

Chemical Properties

Crystalline Solid

Uses

Different sources of media describe the Uses of 13009-99-9 differently. You can refer to the following data:
1. Antibacterial.
2. Antibacterial

Therapeutic Function

Antibacterial

General Description

4-(Aminomethyl)benzenesulfonamide acetate (Sulfamylon)is a homologue of the sulfanilamide molecule. It is not atrue sulfanilamide-type compound, as it is not inhibited byPABA. Its antibacterial action involves a mechanism thatdiffers from that of true sulfanilamide-type compounds. This compound is particularly effective against Clostridiumwelchii in topical application and was used duringWorld War II by the German army for prophylaxis ofwounds. It is not effective orally. It is currently used aloneor with antibiotics in the treatment of slow-healing, infectedwounds.Some patients treated for burns with large quantities ofthis drug have developed metabolic acidosis. To overcomethis adverse effect, a series of new organic salts was prepared. The acetate in an ointment base proved to be themost efficacious.

InChI:InChI=1/C7H10N2O2S.C2H4O2/c8-5-6-1-3-7(4-2-6)12(9,10)11;1-2(3)4/h1-4H,5,8H2,(H2,9,10,11);1H3,(H,3,4)

Downstream Products

• 1350538-25-8 (4R,5S,6S)-3-[[(3S,5S)-N-(4-nitrobenzyloxycarbonyl)-5-[(4-aminosulfonylphen-1-yl)methyl]carbamoyl]-3-pyrrolidinyl]thio-6-[(R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid (4-nitrobenzyl)methyl ester 
• 1312953-83-5 (4R,5S,6S)-6-((R)-1-hydroxyethyl)-4-methyl-7-oxo-3-(((3S,5S)-5-((4-sulfamoylbenzyl)carbamoyl)pyrrolidin-3-yl)thio)-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid 
• 1350538-24-7 (2S,4S)-2-[(4-aminosulfonylphen-1-yl)iminomethylformyl]-4-thiol-1-(p-nitrobenzyloxycarbonyl)pyrrolidine 

Related news

Care reportSerious silver sulphadiazine and Mafenide acetate (cas 13009-99-9) dermatitis☆09/03/2019

Infrequently reported, serious allergic reactions to topical antimicrobial agents used in the treatment of burn injuries are a potential source of confusion. To avoid misdirected therapy, an understanding of the manifestations of such reactions is important. Two recent cases of serious allergic ...detailed

Original contributionComparison between topical honey and Mafenide acetate (cas 13009-99-9) in treatment of auricular burn08/30/2019

The auricle is a frequently injured part of the head and neck during thermal injury leading to ear deformity. The burned ear represents one of the most difficult problems for reconstructive surgeons. Mafenide acetate is a topical agent used routinely for these patients, but it has some disadvant...detailed