130103-40-1

Usage

Molecular Structure

Contains a pyrrole ring, an acetic acid group, a methyl group, and a phenylsulfonyl group.

Role in Synthesis

Used as a building block for the synthesis of various pharmaceuticals and agrochemicals.

Protecting Group

The phenylsulfonyl group can serve as a protecting group in organic synthesis.

Selective Reactions

The protecting group allows for selective reactions to take place.

Potential Applications

Has potential applications in the development of new drugs and the creation of novel chemical entities for various industrial uses.

Upstream product

• 86688-97-3 1-(Phenylsulfonyl)-3-(carbomethoxymethyl)pyrrole 
• 144463-41-2 methyl 2-(1-phenylsulfonylpyrrol-3-yl)propanoate 

Downstream Products

• 130103-48-9 4,7-dimethyl-1-phenylsulfonylpyrano<3,4-b>pyrrol-5(1H)-one 
• 130103-62-7 4,9-dimethyl-1-phenylsulfonylbenzindole 
• 130103-56-9 dimethyl 4,7-dimethyl-1-(phenylsulfonyl)-1H-indole-5,6-dicarboxylate 
• 130103-59-2 ethyl 4,7-dimethyl-1-phenylsulfonylindole-5-carboxylate 
• 130103-57-0 ethyl 4,7-dimethyl-1-phenylsulfonylindole-6-carboxylate 

Relevant academic research and scientific papers

Diels-Alder reactions of 1,5-dihydropyrano[3,4-b]pyrrol-5(1H)-ones, pyrrole-2,3-quinodimethane analogues; a new synthesis of indoles

The pyrano[3,4-b]pyrrol-5-(1H)-ones 7 are stable cyclic analogues of pyrrole-2,3-quinodimethane, and undergo Diels-Alder reaction with a range of acetylenes (dimethyl acetylenedicarboxylate, ethyl propiolate, ethyl trimethylsilylpropynoate, benzyne and the acetylene equivalent, phenyl vinyl sulfoxide), to give, after loss of carbon dioxide, indoles. The Diels-Alder reaction can be extended to the intramolecular variant to give cycloalka-[e]- and [g]-indoles.

Diels-Alder Reactions of 2,3-Dimethylenepyrrole Analogues; a New Synthesis of Indoles

The pyranopyrrol-5(1H)-ones (4) are stable cyclic analogues of 2,3-dimethylenepyrrole and undergo Diels-Alder reaction with a range of acetylenes, or acetylene equivalents, to give, after loss of carbon dioxide, indoles.