130108-75-7

Basic information

• Product Name: 1-[(2R,4S,5R)-5-azido-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4(1H,3H)-dione (non-preferred name)
• Synonyms: 4'-Azido-2'-deoxyuridine; Uridine, 4'-azido-2'-deoxy-
• CAS NO: 130108-75-7
• Molecular Formula: C₉H₁₁N₅O₅
• Molecular Weight: 269.2141
• Mol File: 130108-75-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-[(2R,4S,5R)-5-azido-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4(1H,3H)-dione (non-preferred name)(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[(2R,4S,5R)-5-azido-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4(1H,3H)-dione (non-preferred name)(130108-75-7)
• EPA Substance Registry System: 1-[(2R,4S,5R)-5-azido-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4(1H,3H)-dione (non-preferred name)(130108-75-7)

Safety Data

• Hazardous Substances Data: 130108-75-7(Hazardous Substances Data)

Usage

Chemical structure

The compound has a complex molecular structure, containing a pyrimidine-2,4(1H,3H)-dione ring and a tetrahydrofuran-2-yl group, as well as an azido and hydroxy groups.

Stereochemistry

The compound has a specific stereochemistry, with the R configuration at the 2nd and 5th carbon atoms and the S configuration at the 4th carbon atom.

Functional groups

The compound contains an azido group, a hydroxy group, and a hydroxymethyl group.

Potential applications

The compound may have potential applications in pharmaceuticals, organic synthesis, or as a research tool in chemical biology.

Safety precautions

It is important to handle this compound with care as azido groups can be potentially explosive. Further research and safety precautions are necessary when working with this compound.

Upstream product

• 130109-08-9 4'-azido-2',5'-dideoxy-5'-iodo-3'-O-(4-methoxybenzoyl)uridine 
• 58510-66-0 2',5'-dideoxy-5'-iodouridine 
• 140226-22-8 4'-azido-2',5'-dideoxy-5'-iodouridine 
• 58096-66-5 1-(2,5-dideoxy-β-D-glycero-pent-4-enofuranosyl)uracil 
• 951-78-0 2'-deoxyuridine 

Relevant articles and documents

Antiviral agents

Nucleoside compounds of the formula STR1 wherein: B is a purine or a pyrimidine; X and X' are H, OH or F, provided that at least one is H; Y and Y' are H, OH, OCH3 or F, provided that at least one is H; Y' and Z together form a cyclic phosphate ester, provided that Y is H; or Z is STR2 where n is zero, one, two or three; and Z' is N3 or OCH3 ; provided that when X' and Y' are OH and Z' is N3, B is not cytosine, and when X' and Y' are OH and Z' is OCH3, B is not uracil, adenine or cytosine; and the pharmaceutically acceptable esters, ethers and salts thereof, have been found to have potent antiviral activity with a high therapeutic ratio.