130108-75-7 Usage
Chemical structure
The compound has a complex molecular structure, containing a pyrimidine-2,4(1H,3H)-dione ring and a tetrahydrofuran-2-yl group, as well as an azido and hydroxy groups.
Stereochemistry
The compound has a specific stereochemistry, with the R configuration at the 2nd and 5th carbon atoms and the S configuration at the 4th carbon atom.
Functional groups
The compound contains an azido group, a hydroxy group, and a hydroxymethyl group.
Potential applications
The compound may have potential applications in pharmaceuticals, organic synthesis, or as a research tool in chemical biology.
Safety precautions
It is important to handle 1-[(2R,4S,5R)-5-azido-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4(1H,3H)-dione (non-preferred name) with care as azido groups can be potentially explosive. Further research and safety precautions are necessary when working with 1-[(2R,4S,5R)-5-azido-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4(1H,3H)-dione (non-preferred name).
Check Digit Verification of cas no
The CAS Registry Mumber 130108-75-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,0,1,0 and 8 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 130108-75:
(8*1)+(7*3)+(6*0)+(5*1)+(4*0)+(3*8)+(2*7)+(1*5)=77
77 % 10 = 7
So 130108-75-7 is a valid CAS Registry Number.
130108-75-7Relevant academic research and scientific papers
Antiviral agents
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, (2008/06/13)
Nucleoside compounds of the formula STR1 wherein: B is a purine or a pyrimidine; X and X' are H, OH or F, provided that at least one is H; Y and Y' are H, OH, OCH3 or F, provided that at least one is H; Y' and Z together form a cyclic phosphate ester, provided that Y is H; or Z is STR2 where n is zero, one, two or three; and Z' is N3 or OCH3 ; provided that when X' and Y' are OH and Z' is N3, B is not cytosine, and when X' and Y' are OH and Z' is OCH3, B is not uracil, adenine or cytosine; and the pharmaceutically acceptable esters, ethers and salts thereof, have been found to have potent antiviral activity with a high therapeutic ratio.
Synthesis and anti-HIV activity of 4'-azido- and 4'-methoxynucleosides
Maag,Rydzewski,McRoberts,Crawford-Ruth,Verheyden,Prisbe
, p. 1440 - 1451 (2007/10/02)
A series of nucleosides were synthesized in which the 4'-hydrogen was substituted with either an azido or a methoxy group. The key steps in the syntheses of the 4'-azido analogues were the stereo- and regioselective addition of iodine azide to a 4'-unsatu
