130111-35-2Relevant academic research and scientific papers
Rationally designed N-phenylsulfonylindoles as a tool for the analysis of the non-basic 5-HT6R ligands binding mode
Staroń, Jakub,Bugno, Ryszard,Pietru?, Wojciech,Sata?a, Grzegorz,Mordalski, Stefan,Warszycki, Dawid,Hogendorf, Agata,Hogendorf, Adam S.,Kalinowska-T?u?cik, Justyna,Lenda, Tomasz,Pilarski, Bogus?aw,Bojarski, Andrzej J.
, (2020/10/26)
Among all of the monoaminergic receptors, the 5-HT6R has the highest number of non-basic ligands (approximately 5% of compounds stored in 25th version of ChEMBL database have the strongest basic pKa below 5, calculated using the Instant JChem c
PREPARATION OF ALKYL-SUBSTITUTED INDOLES IN THE BENZENE PORTION. Part 4
Muratake, Hideaki,Natsume, Mitsutaka
, p. 691 - 700 (2007/10/02)
A useful method for the preparation of variously substituted polyalkylindoles (3b) was established by H2SO4-catalyzed cyclization reaction of 1b, where the substituent Y was designated as either the hydroxy or alkoxy group, to yield 3a in good yields.The substrate (1b) was prepared from 1-phenylsulfonylpyrrole (5) by way of 1-phenylsulfonyl-2-pyrrolyl derivatives (4), e.g., 6 and 13, followed by the aldol reaction for the elongation of their carbonyl functions.
