130116-79-9

Basic information

• Product Name: 3,5-bis(1,1-dimethylethyl)-N,4-dihydroxybenzenecarboximidic acid hydrazide
• Synonyms: 3,5-bis(1,1-dimethylethyl)-N,4-dihydroxybenzenecarboximidic acid hydrazide
• CAS NO: 130116-79-9
• Molecular Weight: 283.798
• Mol File: 130116-79-9.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 3,5-bis(1,1-dimethylethyl)-N,4-dihydroxybenzenecarboximidic acid hydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-bis(1,1-dimethylethyl)-N,4-dihydroxybenzenecarboximidic acid hydrazide(130116-79-9)
• EPA Substance Registry System: 3,5-bis(1,1-dimethylethyl)-N,4-dihydroxybenzenecarboximidic acid hydrazide(130116-79-9)

Safety Data

• Hazardous Substances Data: 130116-79-9(Hazardous Substances Data)

Upstream product

• 1620-98-0 3,5-di-t-butyl-4-hydroxybenzaldehyde 
• 787-13-3 3,5-di-tert-butyl-4-hydroxybenzaldehyde oxime 

Downstream Products

• 130116-47-1 4-(5-Amino-[1,2,4]oxadiazol-3-yl)-2,6-di-tert-butyl-phenol 
• 143429-58-7 N-[3-(3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl)-1,2,4-oxadiazol-5-yl]guanidinium methanesulfonate 
• 130116-26-6 2,6-Di-tert-butyl-4-(5-methylsulfanyl-[1,3,4]thiadiazol-2-yl)-phenol 
• 130116-03-9 Cl-986 
• 143429-57-6 N-[3-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-[1,2,4]oxadiazol-5-yl]-guanidine 
• 130116-80-2 3,5-bis(1,1-dimethylethyl)-N,4-dihydroxybenzenecarboximidic acid hydrazide 

Relevant articles and documents

Derivatives of 2-(iminomethyl)amino-phenyl, their preparation, their use as medicaments and the pharmaceutical compositions containing them

The invention relates to new derivatives of 2-(iminomethyl)amino-phenyl which are NO synthase inhibitors and can trap reactive oxygen species. These compounds can notably be used for the treatment of stroke, of neurodegenerative diseases and of ischemic or hemorragic cardiac or cerebral infarctions. These compounds include: N-{4-[({[4-(3,5-di-tert-butyl-4-hydroxyphenyl)-1,3-thiazol-2-yl]methyl}amino)methyl]phenyl}thiophene-2-carboximidamide; N-{3-[({[4-(3,5-di-tert-butyl-4-hydroxyphenyl)-1,3-thiazol-2-yl]methyl}amino)methyl]phenyl}thiophene-2-carboximidamide; N-(4-{[{[4-(3,5-di-tert-butyl-4-hydroxyphenyl)-1,3-thiazol-2-yl]methyl}(methyl)amino]methyl}phenyl)thiophene-2-carboximidamide; N-[3-({[3-(3,5-di-tert-butyl-4-hydroxyphenyl)propyl]amino}methyl)phenyl]thiophene-2-carboximidamide; N-(3-{[(3,5-di-tert-butyl-4-hydroxybenzyl)amino]methyl}phenyl)thiophene-2-carboximidamide; N-[3-({[2-(3,5-di-tert-butyl-4-hydroxyphenyl)ethyl]amino}methyl)phenyl]thiophene-2-carboximidamide; N-[3-({[3-(4-hydroxy-3,5-diisopropylphenyl)propyl]amino}methyl)phenyl]thiophene-2-carboximidamide; N-(3-{[(4-hydroxy-3,5-diisopropylbenzyl)amino]methyl}phenyl) thiophene-2-carboximidamide; N-[3-({[2-(4-hydroxy-3,5-diisopropylphenyl)ethyl]amino}methyl)phenyl]thiophene-2-carboximidamide; N-2-(3,5-di-tert-butyl-4-hydroxybenzoyl)-N-1-(4-{[imino(thien-2-yl)methyl]amino}phenyl)-L-leucinamide; and pharmaceutically acceptable salts thereof.

Derivatives of 2-(iminomethyl)amino-phenyl, their preparation, their use as medicaments and the pharmaceutical compositions containing them

A compound selected from the group consisting of a compound of the formula wherein A is selected from the group consisting of and the other substituents are defined in the specification having an inhibitory activity of NO-synthase enzymes producing nitrogen mono-oxide and/or an activity which traps the reactive oxygen species.

Design of 5-(3,5-di-tert-butyl-4-hydroxyphenyl)-1,3,4-thiadiazoles, - 1,3,4-oxadiazoles, and -1,2,4-triazoles as orally-active, nonulcerogenic antiinflammatory agents

To discover dual inhibitors of 5-lipoxygenase (LO) and cyclooxygenase (CO) with improved pharmacokinetic properties, we have designed and synthesized series of 1,2,4-triazole, 1,3,4-oxadiazole, and 1,3,4-thiadiazole di-tert- butylphenol derivatives which