1301178-77-7

Upstream product

• 944344-35-8 2-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)-3-hydroxybutyl)isoindoline-1,3-dione 
• 41202-77-1 1-(2,3-dichlorophenyl)piperazine 
• 86506-70-9 rac-2-(2-(oxiran-2-yl)ethyl)isoindoline-1,3-dione 

Downstream Products

• 1301178-83-5 N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)-3-fluorobutyl)-benzofuran-2-carboxamide 
• 1301178-85-7 N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)-3-fluorobutyl)-5-methoxybenzofuran-2-carboxamide 
• 1301178-87-9 N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)-3-fluorobutyl)-1H-indole-2-carboxamide 
• 1301178-89-1 N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)-3-fluorobutyl)-9H-fluorene-2-carboxamide 
• 1301178-91-5 N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)-3-fluorobutyl)-benzo[b]thiophene-2-carboxamide 
• 1301178-93-7 N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)-3-fluorobutyl)-5-methoxy-1H-indole-2-carboxamide 
• 1301178-94-8 N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)-3-fluorobutyl)-2-naphthamide 
• 1301179-17-8 N-((9H-fluoren-2-yl)methyl)-4-(4-(2,3-dichlorophenyl)-piperazin-1-yl)-3-fluorobutan-1-amine 
• 1301179-19-0 N-((9H-fluoren-2-yl)methyl)-4-(4-(2,3-dichlorophenyl)-piperazin-1-yl)-3-fluoro-N-methylbutan-1-amine 
• 1301178-79-9 4-(4-(2,3-dichlorophenyl)piperazin-1-yl)-3-fluorobutan-1-amine 
• 1301178-97-1 N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)-3-fluorobutyl)-5-methoxybenzofuran-2-carboxamide oxalate 
• 1301178-98-2 N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)-3-fluorobutyl)-1H-indole-2-carboxamide oxalate 
• 1301178-99-3 N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)-3-fluorobutyl)-9H-fluorene-2-carboxamide oxalate 
• 1301178-81-3 C₂₆H₂₇Cl₂FN₄O 

Relevant academic research and scientific papers

PHENYL CARBAMATES AND THEIR USE AS INHIBITORS OF THE FATTY ACID AMIDE HYDROLASE (FAAH) ENZYME AND MODULATORS OF THE D3 DOPAMINE RECEPTOR (D3DR)

The invention provides compounds of Formula (I) or pharmaceutically acceptable salts thereof wherein Ar', R1, R2, R3, R4, X, Y are as defined in the description of invention, as multi-target directed ligands (MT

Chiral resolution and serendipitous fluorination reaction for the selective dopamine d3 receptor antagonist BAK2-66

The improved chiral synthesis of the selective dopamine D3 receptor (D3R) antagonist (R)-N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)-3-hydroxybutyl)1H- indole-2-carboxamide ((R)-PG648) is described. The same chiral secondary alcohol intermediate was used to prepare the enantiomers of a 3-F-benzofuranyl analogue, BAK 2-66. The absolute configurations of the 3-F enantiomers were assigned from their X-ray crystal structures that confirmed retention of configuration during fluorination with N,N-diethylaminosulfur trifluoride (DAST). (R)-BAK2-66 showed higher D3R affinity and selectivity than its (S)-enantiomer; however, it had lower D3R affinity and enantioselectivity than (R)-PG648. Further, importance of the 4-atom linker length between the aryl amide and 4-phenylpiperazine was demonstrated with the 4-fluorobutyl-product (8). This article not subject to U.S. Copyright. Published 2014 by the American Chemical Society.

N -(3-Fluoro-4-(4-(2-methoxy or 2,3-dichlorophenyl)piperazine-1-yl)butyl) arylcarboxamides as selective dopamine D3 receptor ligands: Critical role of the carboxamide linker for d3 receptor selectivity

N-(3-Fluoro-4-(4-(2,3-dichloro- or 2-methoxyphenyl)piperazine-1-yl)butyl) arylcarboxamides were prepared and evaluated for binding and function at dopamine D3 receptors (D3Rs) and dopamine D2 receptors (D2Rs). In this series, we discovered some of the mos