1301214-62-9

Basic information

• Product Name: 7-Carboxy-1-hydroxyisoquinoline, 7-Carboxy-1-hydroxy-2-azanaphthalene
• Synonyms: 1-Hydroxyisoquinoline-7-carboxylic acid;7-Carboxy-1-hydroxyisoquinoline, 7-Carboxy-1-hydroxy-2-azanaphthalene;1-oxo-1,2-dihydroisoquinoline-7-carboxylic acid
• CAS NO: 1301214-62-9
• Molecular Formula: C10H7NO3
• Molecular Weight: 189.16748
• Mol File: 1301214-62-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 526.1±50.0 °C(Predicted)
• Appearance: /
• Density: 1.405±0.06 g/cm3(Predicted)
• PKA: 4.02±0.20(Predicted)
• CAS DataBase Reference: 7-Carboxy-1-hydroxyisoquinoline, 7-Carboxy-1-hydroxy-2-azanaphthalene(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Carboxy-1-hydroxyisoquinoline, 7-Carboxy-1-hydroxy-2-azanaphthalene(1301214-62-9)
• EPA Substance Registry System: 7-Carboxy-1-hydroxyisoquinoline, 7-Carboxy-1-hydroxy-2-azanaphthalene(1301214-62-9)

Safety Data

• Hazardous Substances Data: 1301214-62-9(Hazardous Substances Data)

Upstream product

• 658082-39-4 methyl 1-oxo-2H-isoquinoline-7-carboxylate 
• 1184913-64-1 1-oxo-1,2-dihydroisoquinoline-7-carbonitrile 
• 223671-15-6 7-bromo-1(2H)-isoquinolone 

Downstream Products

• 1374258-53-3 ethyl 1-(4-methoxybenzylamino)isoquinoline-7-carboxylate 
• 1374258-54-4 1-(4-methoxybenzylamino)isoquinoline-7-carboxylic acid 

Relevant articles and documents

INHIBITORS OF ENL/AF9 YEATS

Methods and compositions for treating leukemia are disclosed. Acylated 6-aminoindoles, acylated 6-aminopyrrolopyridines and acylated 3-aminopyrrolo[3,2-c]pyridazines of the following formula inhibit ENL/AF9 YEATS and are therefore useful for treating leukemia.

N2-PYRAZOLOSPIROKETONE ACETYL-COA CARBOXYLASE INHIBITORS

The invention provides a compound of Formula (I) or a pharmaceutically acceptable salt of said compound, wherein R1, R2, R3 and R4 are as described herein; pharmaceutical compositions thereof; and the use thereof in treating diseases, conditions or disorders modulated by the inhibition of an acetyl- CoA carboxylase enzyme(s) in an animal.