1301214-71-0

Basic information

• Product Name: N-(5-broMo-2-Methylpyridin-3-yl)acetaMide
• Synonyms: N-(5-broMo-2-Methylpyridin-3-yl)acetaMide;N-(5-bromo-2-methyl-3-pyridinyl)acetamide
• CAS NO: 1301214-71-0
• Molecular Formula: C₈H₉BrN₂O
• Molecular Weight: 229.07386
• Mol File: 1301214-71-0.mol
• Article Data: 18

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: N-(5-broMo-2-Methylpyridin-3-yl)acetaMide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(5-broMo-2-Methylpyridin-3-yl)acetaMide(1301214-71-0)
• EPA Substance Registry System: N-(5-broMo-2-Methylpyridin-3-yl)acetaMide(1301214-71-0)

Safety Data

• Hazardous Substances Data: 1301214-71-0(Hazardous Substances Data)

Usage

General Description

N-(5-bromo-2-methylpyridin-3-yl)acetamide is a chemical compound that belongs to the class of amides. It is derived from pyridine, a heterocyclic organic compound, and contains a bromine atom on the 5th position and a methyl group on the 2nd position of the pyridine ring. The acetamide group is attached to the 3rd position of the pyridine ring. N-(5-broMo-2-Methylpyridin-3-yl)acetaMide is commonly used in organic synthesis and pharmaceutical research as an intermediate for the synthesis of various biologically active compounds. It has potential applications in the development of new drugs and agrochemicals.

Upstream product

• 914358-73-9 5-bromo-2-methylpyridin-3-ylamine 
• 108-24-7 acetic anhydride 
• 67443-38-3 5-bromo-2-chloro-3-nitropyridine 
• 911434-05-4 5-bromo-2-methyl-3-nitropyridine 
• 911434-04-3 2-(5-bromo-3-nitro-pyridin-2-yl)-malonic acid diethyl ester 

Downstream Products

• 1256807-59-6 1H-pyrazolo[4,3-b] pyridine-6-carboxylic acid 

Relevant articles and documents

Efficient synthesis of novel pyridine-based derivatives via suzuki cross-coupling reaction of commercially available 5-bromo-2-methylpyridin-3-amine: Quantum mechanical investigations and biological activities

The present study describes palladium-catalyzed one pot Suzuki cross-coupling reaction to synthesize a series of novel pyridine derivatives 2a-2i, 4a-4i. In brief, Suzuki cross-coupling reaction of 5-bromo-2-methylpyridin-3-amine (1) directly or via N-[5-bromo-2-methylpyridine-3-yl]acetamide (3) with several arylboronic acids produced these novel pyridine derivatives in moderate to good yield. Density functional theory (DFT) studies were carried out for the pyridine derivatives 2a-2i and 4a-4i by using B3LYP/6-31G(d,p) basis with the help of GAUSSIAN 09 suite programme. The frontier molecular orbitals analysis, reactivity indices, molecular electrostatic potential and dipole measurements with the help of DFT methods, described the possible reaction pathways and potential candidates as chiral dopants for liquid crystals. The anti-thrombolytic, biofilm inhibition and haemolytic activities of pyridine derivatives were also investigated. In particular, the compound 4b exhibited the highest percentage lysis value (41.32%) against clot formation in human blood among all newly synthesized compounds. In addition, the compound 4f was found to be the most potent against Escherichia coli with an inhibition value of 91.95%. The rest of the pyridine derivatives displayed moderate biological activities.

HETEROARYL COMPOUNDS AS NECROSIS INHIBITORS, COMPOSITION AND METHOD USING THE SAME

The present disclosure provides heteroaryl compounds of Formula (I), processes for their preparation, pharmaceutical compositions containing them, and their use in the treatment of diseases and disorders, arising from or related to necrosis. Formula (I) i

PYRIMIDINE AND PYRIDINE DERIVATIVES AND USE IN TREATMENT, AMELIORATION OR PREVENTION OF INFLUENZA THEREOF

Provided herein is a compound of formula (I), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, prodrug, codrug, cocrystal, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, which is useful in treating, ameliorating or preventing influenza.