1301265-06-4Relevant academic research and scientific papers
Identification of 3-sulfonylindazole derivatives as potent and selective 5-HT6 antagonists
Liu, Kevin G.,Robichaud, Albert J.,Greenfield, Alexander A.,Lo, Jennifer R.,Grosanu, Cristina,Mattes, James F.,Cai, Yanxuan,Zhang, Guo Ming,Zhang, Jean Y.,Kowal, Dianne M.,Smith, Deborah L.,Di, Li,Kerns, Edward H.,Schechter, Lee E.,Comery, Thomas A.
, p. 650 - 662 (2011)
As part of our efforts to develop agents for cognitive enhancement, we have been focused on the 5-HT6 receptor in order to identify potent and selective ligands for this purpose. Herein we report the identification of a novel series of 3-sulfonylindazole derivatives with acyclic amino side chains as potent and selective 5-HT6 antagonists. The synthesis and detailed SAR of this class of compounds are reported.
