13017-50-0Relevant articles and documents
Determination of heats of tautomerization of nitrile-ketenimine by mass spectrometry
Saraví Cisneros, Hebe,Erben, Mauricio F.,Della Védova, Carlos O.,Laurella, Sergio,Allegretti, Patricia E.,Furlong, Jorge J.P.
, p. 125 - 143 (2011)
Tautomerism of some nitriles has been studied by mass spectrometry. The analysis of the corresponding mass spectra has allowed some fragmentations to specific tautomers to be assigned and the heats of tautomerization to be determined through temperature effects and electron energy studies. Experimental determinations are supported by theoretical calculations. The joint analysis of mass spectrometry and DFT-B3LYP data indicate that this tautomeric equilibrium can be studied by the experimental spectrometric strategy employed.
A convenient and selective one-pot method for the synthesis of monosubstituted secondary alkyl malononitriles
Sammelson, Robert E.,Allen, Mark J.
, p. 543 - 546 (2005)
We have found that α,α-dicyanoalkenes can be efficiently and selectively reduced to α,α-dicyanoalkanes (malononitriles) with NaBH4 in 95% EtOH at 0 °C. In addition, we have determined that the condensation of malononitrile with ketones using absorption alumina as a catalyst can be followed directly, in one pot, by reduction with NaBH 4 in 95% EtOH at 0 °C to provide the monosubstituted secondary alkyl malononitriles in good to excellent yields (42-94%). This procedure provides a convenient alternative to direct alkylation of malononitrile or reduction of α,α-dicyanoalkene intermediates.
A simple, efficient and green procedure for Knoevenagel condensation catalyzed by [C4dabco][BF4] ionic liquid in water
Xu, Da-Zhen,Liu, Yingjun,Shi, Sen,Wang, Yongmei
experimental part, p. 514 - 517 (2010/08/04)
A convenient and rapid method for Knoevenagel condensation has been developed by using DABCO-base ionic liquid catalysts. This method is applicable to a wide range of aromatic/aliphatic/heterocyclic/α,β-unsaturated aldehydes and ketones with active methyl
