13017-69-1

Usage

Biological Activity

Inhibitor of regulator of G-protein signaling 4 (RGS4). Reduces the RGS4-G α o protein-protein interaction signal.

InChI:InChI=1/C11H10N4/c1-3-4-9(2)10(5-12,6-13)11(9,7-14)8-15/h3-4H2,1-2H3

Upstream product

• 107-87-9 2-Pentanone 
• 109-77-3 malononitrile 
• 1885-22-9 bromomalononitrile 
• 13017-51-1 2-(1-methylbutylidene)-malononitrile 

Relevant academic research and scientific papers

Electrochemical transformation of malononitrile and carbonyl compounds into functionally substituted cyclopropanes: Electrocatalytic variant of the Wideqvist reaction

Electrolysis of malononitrile and carbonyl compounds in the presence of alkali metal halides in an undivided cell results in the formation of substituted 1,1,2,2-tetracyanocyclopropanes in 60-90% yield. This electrocatalytic variant of the Wideqvist reaction using malononitrile instead of bromomalonitrile was successfully performed. Electrocatalytic transformation of substituted 1,1,2,2-tetracyanocyclopropanes in methanol or ethanol in an undivided cell leads to substituted 2-amino-4,4-dialkoxy-1,5- dicyano-3-azabicyclo[3.1.0]hex-2-enes in 70-95% yields after 0.05-0.10 F/mol of electricity has been passed. (C) 2000 Elsevier Science Ltd.

Electrochemical transformation of malononitrile and ketones into 3,3-disubstituted-1,1,2,2-tetracyanocyclopropanes

Electrolysis of malononitrile in the presence of ketones and NaBr in ethanol in undivided cell results in formation of 3,3-disubstituted-1,1,2,2-tetracyanocyclopropanes