1301714-93-1

Basic information

• Product Name: C₂₂H₂₅NO₃
• CAS NO: 1301714-93-1
• Molecular Weight: 351.445
• Mol File: 1301714-93-1.mol

Chemical Properties

• CAS DataBase Reference: C₂₂H₂₅NO₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₂₅NO₃(1301714-93-1)
• EPA Substance Registry System: C₂₂H₂₅NO₃(1301714-93-1)

Safety Data

• Hazardous Substances Data: 1301714-93-1(Hazardous Substances Data)

Upstream product

• 148435-94-3 ethyl 3-(4-aminophenyl)-2-propenoate hydrochloride 
• 51631-26-6 α-isopropyl-α-phenylacetyl chloride 

Downstream Products

• 1301715-23-0 C₂₆H₂₇N₃O₂ 
• 1228571-25-2 C₂₀H₂₂N₂O₃ 
• 1301715-07-0 C₂₀H₂₁NO₃ 

Relevant articles and documents

Novel Cinnamyl Hydroxyamides and 2-Aminoanilides as Histone Deacetylase Inhibitors: Apoptotic Induction and Cytodifferentiation Activity

Four novel series of cinnamyl-containing histone deacetylase (HDAC) inhibitors 1-4 are described, containing hydroxamate (1 and 3) or 2-aminoanilide (2 and 4) derivatives. When screened against classI (maize HD1-B and human HDAC1) and classII (maize HD1-A and human HDAC4) HDACs, most hydroxamates and 2-aminoanilides displayed potent and selective inhibition toward classI enzymes. Immunoblotting analyses performed in U937 leukemia cells generally revealed high acetyl-H3 and low acetyl-α-tubulin levels. Exceptions are compounds 3f-i, 3m-o, and 4k, which showed higher tubulin acetylation than SAHA. In U937 cells, cell-cycle blockade in either the G2/M or G1/S phase was observed with 1-4. Five hydroxamates (compounds 1h-l) effected a two- to greater than threefold greater percent apoptosis than SAHA, and in the CD11c cytodifferentiation test some 2-aminoanilides belonging to both series 2 and 4 were more active than MS-275. The highest-scoring derivatives in terms of apoptosis (1k, 1l) or cytodifferentiation (2c, 4n) also showed antiproliferative activity in U937 cells, thus representing valuable tools for study in other cancer contexts.