130172-78-0

Basic information

• Product Name: (Z)-4-[(1R,2R,3R,5S)-5-(tert-Butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-cyclohexyl-3-(tetrahydro-pyran-2-yloxy)-propenyl]-3-(tetrahydro-pyran-2-yloxy)-cyclopentyl]-but-2-enoic acid methyl ester
• CAS NO: 130172-78-0
• Molecular Weight: 620.943
• Mol File: 130172-78-0.mol

Chemical Properties

• CAS DataBase Reference: (Z)-4-[(1R,2R,3R,5S)-5-(tert-Butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-cyclohexyl-3-(tetrahydro-pyran-2-yloxy)-propenyl]-3-(tetrahydro-pyran-2-yloxy)-cyclopentyl]-but-2-enoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-4-[(1R,2R,3R,5S)-5-(tert-Butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-cyclohexyl-3-(tetrahydro-pyran-2-yloxy)-propenyl]-3-(tetrahydro-pyran-2-yloxy)-cyclopentyl]-but-2-enoic acid methyl ester(130172-78-0)
• EPA Substance Registry System: (Z)-4-[(1R,2R,3R,5S)-5-(tert-Butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-cyclohexyl-3-(tetrahydro-pyran-2-yloxy)-propenyl]-3-(tetrahydro-pyran-2-yloxy)-cyclopentyl]-but-2-enoic acid methyl ester(130172-78-0)

Safety Data

• Hazardous Substances Data: 130172-78-0(Hazardous Substances Data)

Upstream product

• 88738-78-7 bis-(2,2,2-trifluoroethyl)(methoxycarbonylmethyl)phosphonate 
• 120891-38-5 [(1R,2R,3R,5S)-5-(tert-Butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-cyclohexyl-3-(tetrahydro-pyran-2-yloxy)-propenyl]-3-(tetrahydro-pyran-2-yloxy)-cyclopentyl]-acetaldehyde 

Downstream Products

• 130274-01-0 (5E,13E)-(9S,11R,15S)-11,15-bis(tetrahydropyran-2-yloxy)-15-cyclohexyl-9-hydroxy-3-oxa-16,17,18,19,20-pentanor-5,13-prostadienoic acid t-butyl ester 
• 120891-43-2 {(Z)-4-[(1R,2R,3R,5S)-2-[(E)-(S)-3-Cyclohexyl-3-(tetrahydro-pyran-2-yloxy)-propenyl]-5-hydroxy-3-(tetrahydro-pyran-2-yloxy)-cyclopentyl]-but-2-enyloxy}-acetic acid tert-butyl ester 
• 120891-35-2 {(Z)-4-[(1R,2R,3R,5R)-5-Chloro-2-[(E)-(S)-3-cyclohexyl-3-(tetrahydro-pyran-2-yloxy)-propenyl]-3-(tetrahydro-pyran-2-yloxy)-cyclopentyl]-but-2-enyloxy}-acetic acid tert-butyl ester 
• 120891-34-1 ZK 118882 
• 130172-79-1 {(Z)-4-[(4R,5R)-5-((E)-(S)-3-Cyclohexyl-3-hydroxy-propenyl)-4-hydroxy-cyclopent-1-enyl]-but-2-enyloxy}-acetic acid tert-butyl ester 
• 120891-44-3 ZK 118182 
• 170290-97-8 (5E,13E)-(9S,11R,15S)-11,15-bis(tetrahydropyran-2-yloxy)-9-(t-butyldimethylsiloxy)-15-cyclohexyl-2,3,4,16,17,18,19,20-octanor-5,13-prostadienol 

Relevant articles and documents

Synthesis of a chemically and metabolically stable and biologically potent PGD2-analogue

The metabolic labile α-chain of the PGD2-analogue 2 (ZK 110841) can be stabilized by introduction of an β-oxygen-atom resulting in 3 (ZK 118182), which has a much higher and longer lasting biological activity on oral application in rats. The synthetic methodology for the synthesis of 3-oxa-Z-Δ5,6-prostaglandins will be discussed.