1301741-60-5Relevant academic research and scientific papers
Design and optimisation of orally active TLR7 agonists for the treatment of hepatitis C virus infection
Tran, Thien-Duc,Pryde, David C.,Jones, Peter,Adam, Fiona M.,Benson, Neil,Bish, Gerwyn,Calo, Frederick,Ciaramella, Guiseppe,Dixon, Rachel,Duckworth, Jonathan,Fox, David N.A.,Hay, Duncan A.,Hitchin, James,Horscroft, Nigel,Howard, Martin,Gardner, Iain,Jones, Hannah M.,Laxton, Carl,Parkinson, Tanya,Parsons, Gemma,Proctor, Katie,Smith, Mya C.,Smith, Nicholas,Thomas, Amy
, p. 2389 - 2393 (2011/05/15)
The synthesis and structure-activity relationships of a series of novel interferon inducers are described. Pharmacokinetic studies and efficacy assessment of a series of 8-oxo-3-deazapurine analogues led to the identification of compound 33, a potent and selective agonist of the TLR7 receptor with an excellent in vivo efficacy profile in a mouse model.
