1301751-69-8

Basic information

• Product Name: 4-(4-methoxyphenyl)-5-(3-methoxy-4,5-methylenedioxyphenyl)-1H-pyrazol-3-amine
• CAS NO: 1301751-69-8
• Molecular Weight: 339.351
• Mol File: 1301751-69-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(4-methoxyphenyl)-5-(3-methoxy-4,5-methylenedioxyphenyl)-1H-pyrazol-3-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-methoxyphenyl)-5-(3-methoxy-4,5-methylenedioxyphenyl)-1H-pyrazol-3-amine(1301751-69-8)
• EPA Substance Registry System: 4-(4-methoxyphenyl)-5-(3-methoxy-4,5-methylenedioxyphenyl)-1H-pyrazol-3-amine(1301751-69-8)

Safety Data

• Hazardous Substances Data: 1301751-69-8(Hazardous Substances Data)

Upstream product

• 5780-07-4 3-methoxy-4,5-methylenedioxybenzaldehyde 
• 487-62-7 isomyristicin 
• 1240140-17-3 2-(4-methoxyphenyl)-3-oxo-3-(3-methoxy-4,5-methylenedioxyphenyl)propanenitrile 
• 22934-58-3 methyl 7-methoxybenzo[d][1,3]dioxole-5-carboxylate 
• 607-91-0 myristicin 
• 526-34-1 5-methoxy-3,4-methylenedioxybenzoic acid 

Relevant articles and documents

Cis -restricted 3-aminopyrazole analogues of combretastatins: Synthesis from plant polyalkoxybenzenes and biological evaluation in the cytotoxicity and phenotypic sea urchin embryo assays

We have synthesized a series of novel cis-restricted 4,5-polyalkoxydiaryl- 3-aminopyrazole analogues of combretastatins via short synthetic sequences using building blocks isolated from dill and parsley seed extracts. The resulting compounds were tested in vivo in the phenotypic sea urchin embryo assay to reveal their antimitotic and antitubulin effects. The most potent aminopyrazole, 14a, altered embryonic cell division at 10 nM concentration, exhibiting microtubule-destabilizing properties. Compounds 12a and 14a displayed pronounced cytotoxicity in the NCI60 anticancer drug screen, with the ability to inhibit growth of multi-drug-resistant cancer cells.