1301760-65-5Relevant academic research and scientific papers
Synthesis and SAR of novel benzoxaboroles as a new class of β-lactamase inhibitors
Xia, Yi,Cao, Kathy,Zhou, Yasheen,Alley,Rock, Fernando,Mohan, Manisha,Meewan, Maliwan,Baker, Stephen J.,Lux, Sarah,Ding, Charles Z.,Jia, Guofeng,Kully, Maureen,Plattner, Jacob J.
, p. 2533 - 2536 (2011/05/15)
A new class of benzoxaborole β-lactamase inhibitors were designed and synthesized. 6-Aryloxy benzoxaborole 22 inhibited AmpC P99 and CMY-2 with K i values in the low nanomolar range. Compound 22 restored antibacterial activity of ceftazidime against Enterobacter cloacae P99 expressing AmpC, a class C β-lactamase enzyme. The SAR around the arylbenzoxaboroles, which included the influence of linker and substitutions was also established.
