130178-43-7Relevant articles and documents
Ligand recognition in μ opioid receptor: Experimentally based modeling of μ opioid receptor binding sites and their testing by ligand docking
Sagara, Takeshi,Egashira, Hiromu,Okamura, Mikako,Fujii, Ikuo,Shimohigashi, Yasuyuki,Kanematsu, Ken
, p. 2151 - 2166 (1996)
For three-dimensional understanding of the mechanisms that control potency and selectivity of the ligand binding at the atomic level, we have analysed opioid receptor-ligand interaction based on the receptor's 3D mode. As a first step, we have constructed molecular models for the multiple opioid receptor subtypes using bacteriorhodopsin as a template. The S-activated dihydromorphine derivatives should serve as powerful tools in mapping the three-dimensional structure of the μ opioid receptor, including the nature of the agonist-mediated conformational change that permits G protein-coupling to 'second messenger' effector molecules, and in identifying specific ligand-binding contacts with the μ opioid receptor. The analyses of the interactions of some opioid ligands with the predicted ligand binding sites are consistent with the results of the affinity labeling experiments.
