130187-71-2

Basic information

• Product Name: 2-[(1-ADAMANTYLOXY)METHYL]OXIRANE
• Synonyms: 2-[(1-ADAMANTYLOXY)METHYL]OXIRANE;oxirane, 2-[(tricyclo[3.3.1.1~3,7~]dec-1-yloxy)methyl]-
• CAS NO: 130187-71-2
• Molecular Formula: C₁₃H₂₀O₂
• Molecular Weight: 208.3
• Product Categories: Adamantane derivatives
• Mol File: 130187-71-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 130-135 °C(Press: 10 Torr)
• Appearance: /
• Density: 1.13±0.1 g/cm3(Predicted)
• CAS DataBase Reference: 2-[(1-ADAMANTYLOXY)METHYL]OXIRANE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(1-ADAMANTYLOXY)METHYL]OXIRANE(130187-71-2)
• EPA Substance Registry System: 2-[(1-ADAMANTYLOXY)METHYL]OXIRANE(130187-71-2)

Safety Data

• Hazardous Substances Data: 130187-71-2(Hazardous Substances Data)

Usage

General Description

2-[(1-Adamantyloxy)methyl]oxirane, also known as ADOX, is a chemical compound that belongs to the group of epoxy compounds. It is a colorless liquid with a molecular formula of C15H24O2, and is primarily used as a reactant in the synthesis of various organic compounds. ADOX is known for its stability and low reactivity, making it a useful building block in organic chemistry. It is also used in the production of advanced materials, pharmaceuticals, and agrochemicals. The presence of the adamantyl group in ADOX gives it unique properties and enhances its stability, making it a valuable compound in the field of organic synthesis.

Upstream product

• 768-95-6 1-adamanthanol 
• 106-89-8 epichlorohydrin 

Relevant articles and documents

SYNTHESIS AND ANTIVIRAL ACTIVITY OF ADAMANTYLOXIRANES AND THEIR DERIVATIVES

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Novel carvedilol analogues that suppress store-overload-induced Ca 2+ release

Carvedilol is a uniquely effective drug for the treatment of cardiac arrhythmias in patients with heart failure. This activity is in part because of its ability to inhibit store-overload-induced calcium release (SOICR) through the RyR2 channel. We describe the synthesis, characterization, and bioassay of ca. 100 compounds based on the carvedilol motif to identify features that correlate with and optimize SOICR inhibition. A single-cell bioassay was employed on the basis of the RyR2-R4496C mutant HEK-293 cell line in which calcium release from the endoplasmic reticulum through the defective channel was measured. IC50 values for SOICR inhibition were thus obtained. The compounds investigated contained modifications to the three principal subunits of carvedilol, including the carbazole and catechol moieties, as well as the linker chain containing the β-amino alcohol functionality. The SAR results indicate that significant alterations are tolerated in each of the three subunits.