130187-71-2

Usage

Uses

Used in Organic Synthesis:
ADOX is used as a reactant in the synthesis of various organic compounds due to its stability and low reactivity. Its unique properties make it a preferred choice for constructing complex organic molecules in the field of organic chemistry.
Used in Advanced Materials Production:
2-[(1-ADAMANTYLOXY)METHYL]OXIRANE is utilized in the production of advanced materials, where its stability and unique properties contribute to the development of high-performance materials with specific characteristics.
Used in Pharmaceutical Industry:
ADOX is employed in the pharmaceutical sector for the synthesis of various pharmaceuticals. Its stability and reactivity profile make it a suitable candidate for the development of new drug molecules.
Used in Agrochemicals Production:
In the agrochemical industry, ADOX is used for the synthesis of agrochemicals, where its properties can be leveraged to create effective and stable products for agricultural applications.

Upstream product

• 768-95-6 1-adamanthanol 
• 106-89-8 epichlorohydrin 

Relevant academic research and scientific papers

STORE OVERLOAD-INDUCED CALCIUM RELEASE INHIBITORS AND METHODS FOR PRODUCING AND USING THE SAME

The present invention provides compounds having store overload-induced Ca2+ release (SOICR) inhibitory activity and methods for producing and using the same. In particular, compounds of the invention is of the formula: R1-X1-L-X2-R2, wherein R1, X1, L, X2, and R2 are those defined herein.

Novel carvedilol analogues that suppress store-overload-induced Ca 2+ release

Carvedilol is a uniquely effective drug for the treatment of cardiac arrhythmias in patients with heart failure. This activity is in part because of its ability to inhibit store-overload-induced calcium release (SOICR) through the RyR2 channel. We describe the synthesis, characterization, and bioassay of ca. 100 compounds based on the carvedilol motif to identify features that correlate with and optimize SOICR inhibition. A single-cell bioassay was employed on the basis of the RyR2-R4496C mutant HEK-293 cell line in which calcium release from the endoplasmic reticulum through the defective channel was measured. IC50 values for SOICR inhibition were thus obtained. The compounds investigated contained modifications to the three principal subunits of carvedilol, including the carbazole and catechol moieties, as well as the linker chain containing the β-amino alcohol functionality. The SAR results indicate that significant alterations are tolerated in each of the three subunits.

THE EFFECT OF SOLVENT POLARITY ON THE CONFORMATIONAL EQUILIBRIUM IN GLYCIDYL AND THIOGLYCIDYL ETHERS AND ESTERS

It was shown by PMR spectroscopy that the conformational equilibrium in the glycidyl and thioglycidyl ethers and esters of 1-adamantanol and 1-adamantanecarboxylic acid is displaced toward the most polar conformation.It was found that the geminal spin-spin coupling constant of the protons of the exocyclic methylene group in 1-adamantyl thioglycidyl ether increases with increase in the polarity of the medium.