130188-91-9Relevant academic research and scientific papers
Functionalization of Alkynes and Alkenes Using a Cascade Reaction Approach: Synthesis of β-Keto Sulfones under Metal-free Conditions
Kumar, Mukesh,Ahmed, Riyaz,Singh, Maninder,Sharma, Shweta,Thatikonda, Thanusha,Singh, Parvinder Pal
, p. 716 - 725 (2020)
Here, we are reporting a multicomponent cascade reaction approach for the synthesis of β-keto sulfones by exploiting differential reactivity pattern of substrates under open-atmosphere and metal-free conditions. The coupling partners are aryldiazonium salts, unsaturated compounds, and DABSO. The optimized conditions worked well with both alkenes and alkynes. Moreover, the reaction also works with metabisulfite for the source of sulfone. The controlled liquid chromatography-mass spectrometry and 18O-labelled experiments suggested that air is a source of the incoming oxygen atom of the keto group of β-keto sulfones.
Preparation method of beta-arone substituted sulfone compounds
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Paragraph 0028; 0029; 0030; 0031; 0032; 0069-0072, (2016/10/10)
The invention provides a preparation method of beta-arone substituted sulfone compounds. In the method, olefin azide and sulfonyl hydrazide are used as start raw materials; and in an organic solvent, potassium iodide serves as a catalyst while tert-butyl hydroperoxide serves as an oxidizing agent, and the beta-arone substituted sulfone compounds are generated by reactions, wherein the reaction temperature is room temperature, and the reaction time is 2-4 hours. The preparation method provided by the invention has the advantages that the design is reasonable, the raw materials are easily available, no metal catalyst is involved, the reaction conditions are mild, high-temperature backflow is not required, the method is safe and convenient, the yield is high, and the yield of most products is over 70%. The preparation method provided by the invention is an easy-to-operate method for quickly establishing beta-arone substituted sulfone compounds in a mild and diversified manner, wherein the two start raw materials can be obtained by a one-step method, and the reaction raw materials are cheap and easily available. The general formula I of the beta-arone substituted sulfone compounds is shown in the specification.
