13019-20-0Relevant articles and documents
Process for preparing 3,3-disubstituted oxindoles and thio-oxindoles
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Page/Page column 17, (2008/06/13)
Methods for preparing oxindole and thio-oxindole compounds are provided, which compounds are useful as precursors to useful pharmaceutical compounds. Specifically provided are methods for preparing 5-pyrrole-3,3-oxindole compounds and 5-(7-fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-1-methyl-1H-pyrrole-2-carbonitrile. Also provided are methods for preparing iminobenzo[b]thiophene and benzo[b]thiophenone compounds.
Solvation effects in the Grignard reaction with carbonyl compounds
Sassian, Meeri,Tuulmets, Ants
, p. 82 - 90 (2007/10/03)
Ratios of the yields of addition and reduction products for the reactions of butylmagnesium chloride with diisopropyl ketone, methyl 2-methylpropanoate, and isopropyl 2-methylpropanoate in toluene were determined at different THF, diethyl ether, and tert-
Preparation of ketones via the palladium-catalyzed cross-coupling of acid chlorides with trialkylboranes
Kabalka, George W.,Malladi, Rama R.,Tejedor, David,Kelley, Shane
, p. 999 - 1001 (2007/10/03)
Trialkylboranes react with acid chlorides in the presence of palladium to generate alkyl and aryl ketones in good yields. (C) 2000 Elsevier Science Ltd.
Oxidation of Secondary Alcohols Using Raney Nickel
Krafft, Marie E.,Zorc, Branka
, p. 5482 - 5484 (2007/10/02)
A high yield, one-step oxidation procedure has been developed for the selective oxidation of secondary alcohols.
A VERSATILE ACCESS TO UNSYMMETRICAL AND SYMMETRICAL α-DIKETONES VIA ORGANOTIN REAGENTS
Verlhac, Jean-Baptiste,Chanson, Evelyne,Jousseaume, Bernard,Quintard, Jean-Paul
, p. 6075 - 6078 (2007/10/02)
Unsymmetrical α-diketones have been obtained via cross coupling of acyltins with acyl halides under PdCl2(PPh3)2 catalysis while symmetrical α-diketones have been readily obtained via "in situ" formation of acyltins using hexabutylditin and acyl chlorides under similar experimental conditions.
METAL-HALOGEN EXCHANGE-INITIATED CYCLIZATION OF IODO CARBONYL COMPOUNDS
Cooke, Manning P.,Houpis, Ioannis N.
, p. 4987 - 4990 (2007/10/02)
The feasability of constructing carbocycles through the metal-halogen exchange-initiated cyclization reactions of iodoketones and other carboxyl derivatives has been studied.With saturated primary iodides, cyclization predominates when deactivated ketones are employed.
GRIGNARD REAGENT INDUCED SELF-CONDENSATION OF BENZOXAZOLES: SYNTHESIS OF BENZOXAZOLYLALKYL ALKYL KETONES.
Florio, Saverio,Ingrosso, Giovanni,Sgarra, Riccardo
, p. 3091 - 3094 (2007/10/02)
2-Alkylbenzoxazoles 1 undergo clean Claisen-type self-condensation upon treatment with n-BuMgBr and quenching with aqueous NH4Cl to give 5.In contrast, quenching of the reaction with aqueous HCl furnishes quite good yields of the benzoxazolylalkyl alkyl ketones 8.
GENERAL RELATIONSHIPS IN THE OPENING OF THE OXIRANE RING DURING CLEAVAGE OF GLYCIDIC ACIDS
Kuroyan, R. A.,Markosyan, A. I.,Engoyan, A. P.,Vartanyan, S. A.
, p. 1709 - 1714 (2007/10/02)
By investigation of the decarboxylation of 2,3-epoxy derivatives of acids with various structures it was shown that contrary to the existing theory about the essential opening of the β (C-O) bond in the oxirane ring there are many structural types of 2,3-epoxypropionic acids, in which opening of the α (C-O) bond in the oxirane ring occurs during decarboxylation.It was also shown that these two possible reaction paths can also arise during the decarboxylation of one 2,3-epoxypropionic acid.On the basis of the obtained data a general relationship is developed for theopening of the oxirane ring during the decarboxylation of 2,3-epoxypropionic acids with any structure, and this makes it possible to predict the structure of the obtained carbonyl compound.
Reaction of Lithium Dialkylcuprates with S-2-Pyridiyl Thioates in the Presence of Oxygen. A Carboxylic Ester Synthesis
Kim, Sunggak,Lee, Jae In,Chung, Bong Young
, p. 1231 - 1232 (2007/10/02)
Reaction of lithium dialkylcuprates with S-2-pyridyl thioates in the presence of oxygen affords carboxylic esters in high yields, whereas under nitrogen it affords ketones.