130198-72-0

Usage

General Description

3-(4-aminophenoxy)propionic acid methyl ester is a chemical compound with the molecular formula C11H13NO3. It is a methyl ester derivative of 3-(4-aminophenoxy)propionic acid, which is a synthetic compound often used in the pharmaceutical industry. 3-(4-aminophenoxy)propionic acid methyl ester may have potential biological activity as it contains the amino and carboxyl functional groups, which are commonly found in bioactive molecules. The methyl ester group also provides stability and can enhance the compound's pharmacokinetic properties. Further research may be needed to fully understand the potential uses and properties of 3-(4-aminophenoxy)propionic acid methyl ester.

Upstream product

• 90923-23-2 methyl 3-(4-nitrophenoxy)propionate 

Downstream Products

• 130031-45-7 Acridin-9-yl-(2-{4-[bis-(2-chloro-ethyl)-amino]-phenoxy}-ethyl)-amine 
• 130198-80-0 [4-(2-Amino-ethoxy)-phenyl]-bis-(2-chloro-ethyl)-amine 
• 92318-14-4 3-{4-[bis-(2-chloro-ethyl)-amino]-phenoxy}-propionic acid methyl ester 
• 92019-83-5 3-<4-phenoxy>propionic acid 
• 92431-96-4 methyl 3-<4-phenoxy>propionate 

Relevant academic research and scientific papers

PYRROLE DERIVATIVES AS THERAPEUTIC COMPOUNDS

Novel pyrrole derivatives are disclosed as Aβ42-lowering agents for the treatment and prevention of neurodegenerative disorders characterized by the formation or accumulation of amyloid plaques comprising the Aβ42 peptide.

DNA-Directed Alkylating Agents. 3. Structure-Activity Relationships for Acridine-Linked Aniline Mustards: Consequences of Varying the Length of the Linker Chain

Four series of acridine-linked aniline mustards have been prepared and evaluated for in vitro cytotoxicity, in vivo antitumor activity, and DNA cross-linking ability.The anilines were attached to the DNA-intercalating acridine chromophores by link groups (-O-, -CH2-, -S-, and -SO2-) of widely varying electronic properties, providing four series of widely differing mustard reactivity where the alkyl chain linking the acridine and mustard moieties was varied from two to five carbons.Relationships were sought between chain length and biological properties.Within eachseries, increasing the chain length did not alter the reactivity of the alkylating moiety but did appear to position it differently on the DNA, since cross-linking ability (measured by agarose gel assay) altered with chain length, being maximal with the C4 analogue.The in vivo antitumor activities of the compounds dependend to some extent on the reactivity of the mustard, with the least reactive SO2 compounds being inactive.However, DNA-targeting did appear to allow the use of less reactive mustards, since the S-linked acridine mustards showed significant activity whereas the parent S-mustard did not.Within each active series, the most active compound was the C4 homologue, suggesting some relationship between activity and extent of DNA alkylation.