13020-86-5Relevant academic research and scientific papers
An Improvement of the N-Arylation of Amides; Application to the Synthesis of Substituted 3-(N-Acetyl-N-phenylamino)pyridines
Greiner, Alfred
, p. 312 - 313 (2007/10/02)
In the presence of catalytic quantities of tris(3,6-dioxaheptyl)amine (TDA-1) and of copper(I) chloride, with azeotropic separation of the reaction water, the N-arylation of carboxamides has been simplified and can now be performed under rather mild condi
TDA-1 CATALYSIS IN SMILES REARRANGAMENT OF N-ARYLPHENOXYAMIDES. ACCELERATING EFFECT OF THE 2,4,6-TRICHLORO SUBSTITUTION
Greiner, A.
, p. 931 - 934 (2007/10/02)
Attempted N-alkylation of 3-(2,4,6-trichlorophenoxyacetamido)pyridine, with TDA-1 catalysis, yielded surprisingly N-alkylated 3-(2,4,6-trichlorophenylamino)pyridines through a Smiles rearrangement.
