13022-41-8Relevant academic research and scientific papers
Structure-Activity Relationships of cyclo(l -Tyrosyl- l -tyrosine) Derivatives Binding to Mycobacterium tuberculosis CYP121: Iodinated Analogues Promote Shift to High-Spin Adduct
Rajput, Sunnia,McLean, Kirsty J.,Poddar, Harshwardhan,Selvam, Irwin R.,Nagalingam, Gayathri,Triccas, James A.,Levy, Colin W.,Munro, Andrew W.,Hutton, Craig A.
, p. 9792 - 9805 (2019/11/13)
A series of analogues of cyclo(l-tyrosyl-l-tyrosine), the substrate of the Mycobacterium tuberculosis enzyme CYP121, have been synthesized and analyzed by UV-vis and electron paramagnetic resonance spectroscopy and by X-ray crystallography. The introduction of iodine substituents onto cyclo(l-tyrosyl-l-tyrosine) results in sub-μM binding affinity for the CYP121 enzyme and a complete shift to the high-spin state of the heme FeIII. The introduction of halogens that are able to interact with heme groups is thus a feasible approach to the development of next-generation, tight binding inhibitors of the CYP121 enzyme, in the search for novel antitubercular compounds.
Synthesis and biological evaluation of analogue of delavayin-C: A cyclic heptapeptide
Shinde, Nirmala V.,Himaja,Bhosale,Wagh
scheme or table, p. 996 - 1000 (2012/04/10)
The synthesis of N-methylated analogue of delavayin-C, a cyclic heptapeptide was carried out by using solution phase technique. The structure of this compound was confirmed on the basis of analytical IR, 1H NMR and FAB MASS spectral data. The e
Intramolecular Interaction of Porphyrin Moieties in 2,5-Piperazinedione-Bridged Porphyrin Dimers
Tamiaki, Hitoshi,Suzuki, Shinji,Maruyama, Kazuhiro
, p. 2633 - 2637 (2007/10/02)
Diastereomerically pure 2,5-piperazinedione-bridged meso-tetraarylporphyrin dimers were synthesized with easy procedures. 1H NMR, UV-vis, and CD spectra showed that porphyrin moieties in the L,L-molecule interacted more strongly than those in the D,L-isom
