130247-53-9Relevant academic research and scientific papers
A Rapid and Efficient Synthesis of a Bifunctional β-Silylketone, Precursor for a Solid Supported β-Silylethanol Anchoring Group
Date, Sonali M.,Iyer, Prema,Ghosh, Sunil K.
, p. 405 - 411 (2007/10/03)
A concise synthesis of 3-dimethyl(phenyl)silyl-5-oxo-hexanoic acid 1, the precursor for a solid supported β-silylethanol anchoring group has been achieved from ethyl 2-ethoxycarbonyl-3-dimethyl(phenyl)silyl-2-propenoate 2 featuring amino acid catalysed Mi
An expeditious synthesis of a β-silylethanol anchoring group by a silicon directed Baeyer-Villiger oxidation on solid-phase
Iyer, Prema,Ghosh, Sunil K.
, p. 9437 - 9440 (2007/10/03)
A concise synthesis of a β-silylethanol anchoring group on an aminomethylated Merrifield resin has been achieved from 3-dimethyl(phenyl)silyl-5-oxohexanoic acid featuring a solid-phase silicon directed Baeyer-Villiger oxidation of a β-silylketone as the key step.
Preparation of functionalized Z-olefins using 1,1-dimetalloalkanes
Tucker,Knochel
, p. 530 - 536 (2007/10/02)
1,1-Dimetalloalkanes obtained by the allylzincation of alkenylmagnesium compounds react smoothly with various functionalized alkylidenemalonates providing functionalized Z-olefins in good yields. If dimenthyl alkylidenemalonates are used, then excellent stereoselectivities are observed (92:8 to 100:0). An application to a short stereospecific synthesis of an insect pheromone [(Z)-7-dodecenyl acetate] is described (> 99.9% Z, 70% overall yield).
The Olefination of Functionalized Alkylidenemalonates by 1,1-Dimetalloalkanes: A New Chemo- and Stereoselective Preparation of Functionalized Olefins
Tucker, Charles E.,Rao, S. Achyutha,Knochel, Paul
, p. 5446 - 5448 (2007/10/02)
The polyfunctional alkylidenemalonates 1, readily prepared by an addition-elimination reaction of FG-RCu(CN)ZnI to malonates of type 7, were found to undergo a highly chemoselective and stereoselective olefination reaction with 1,1-dimetalloalkanes of zinc and magnesium.An application to the stereospecific preparation of an insect pheromone 8 is reported.
