130248-05-4

Upstream product

• 71518-96-2 bis(2,4,6-triisopropylphenyl)diselenide 
• 21524-34-5 2,4,6-triisopropyl-1-bromobenzene 
• 130274-31-6 2(((CH₃)2CH)3C₆H₂Se)2*I₂ 

Downstream Products

• 862133-68-4 2-[6-(2,4,6-triisopropyl-phenylselanyl)-hex-5-ynyloxy]-tetrahydro-pyrane 
• 862133-72-0 2-cyclohexylethynylselanyl-1,3,5-triisopropyl-benzene 
• 862133-51-5 1-(2,4,6-triisopropylphenyl)-selenyl-hex-1-yne 
• 862133-57-1 1,3,5-triisopropyl-2-(prop-1-ynylselanyl)-benzene 
• 173197-72-3 (C₅H₅)Fe(C₅H₃(CH(CH₃)N(CH₃)2)SeC₆H₂(CH(CH₃)2)3) 
• 88141-36-0 Methyl 2,4,6-triisopropylphenyl selenide 
• 883453-87-0 (Z)-3-(2,4,6-triisopropyl-phenylselanyl)-undec-2-en-5-ol 
• 883453-91-6 (Z)-trimethyl-[2-(2,4,6-triisopropyl-phenylselanyl)-hept-2-enyl]-silane 

Relevant academic research and scientific papers

Diastereoselective cyclisation of N-alkenylideneamines into 3,4-dihydro-2H-pyrrol-1-ium halides

A number of new chiral 2-(α-bromoalkyl)pyrrolinium salts and 2-(α-selenoalkyl)pyrrolidines were synthesized by the halocyclisation and selenocyclisation, respectively, of N-(alkenylidene)alkylamines and subsequent reduction. These cyclisations were implem

1-Iodo-1-selenoalkenes as versatile alkene 1,1-dianion equivalents. Novel connective approach towards the tetrahydropyran subunit of polycavernoside A

syn-Hydroalumination of 2,4,6-triisopropylphenylselanyl-1-alkynes with DIBAL-H followed by Al/I exchange with I2 afforded exclusively (E)-1-iodo-1-selenoalkenes in good yields. 1-Iodo-1-selenopropene 10 proved to be a convenient 1,1 dianion equivalent, leading to the stereodivergent synthesis of allylsilanes (Z)-6 and (E)-6. Adduct 3, an intermediate in the synthesis of the tetrahydropyran subunit of polycavernoside A, was efficiently synthesised from allylsilane (Z)-6 and aldehyde 7 via an intramolecular Sakurai cyclisation.

Stereoselective synthesis of (E)-1-iodo-1-selenoalkenes via hydroalumination-iodination of 1-alkynyl selenides

syn-Hydroalumination of 2,4,6-triisopropylphenylselanyl-1-alkynes 22 with DIBAL-H, followed by Al/I exchange with I2, afforded selectively the corresponding (E)-1-iodo-1-selenoalkenes in good yields. The sterically hindered 2,4,6-triisopropylphenyl group proved to be mandatory and prevented the formation of undesired by-products.

Leucascandrolide A: Synthesis and Related Studies

The total synthesis of the biologically active marine natural product leucascandrolide A is reported. A convergent strategy is employed, allowing for the rapid assembly of the macrolide moiety. Key steps of our approach include the diastereoselective addi