130256-61-0

Basic information

• Product Name: 2(1H)-Pyrimidinone, 5-fluoro-3,4-dihydro-4-imino- (9CI)
• Synonyms: 2(1H)-Pyrimidinone, 5-fluoro-3,4-dihydro-4-imino- (9CI)
• CAS NO: 130256-61-0
• Molecular Formula: C4H4FN3O
• Molecular Weight: 129.0924632
• Product Categories: PYRIMIDINE
• Mol File: 130256-61-0.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2(1H)-Pyrimidinone, 5-fluoro-3,4-dihydro-4-imino- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2(1H)-Pyrimidinone, 5-fluoro-3,4-dihydro-4-imino- (9CI)(130256-61-0)
• EPA Substance Registry System: 2(1H)-Pyrimidinone, 5-fluoro-3,4-dihydro-4-imino- (9CI)(130256-61-0)

Safety Data

• Hazardous Substances Data: 130256-61-0(Hazardous Substances Data)

Usage

Chemical structure

A pyrimidine derivative with a fluorine atom at the 5th position and an imine group at the 4th position.

Pharmaceutical applications

Potential use in the development of antiviral and anticancer drugs.

Industrial applications

May be used in the production of agrochemicals or materials.

Other properties

None mentioned.

Upstream product

• 71-30-7 cytosine 
• 64-19-7 acetic acid 

Downstream Products

• 85931-95-9 4-methoxyimino-5-fluoropyrimidin-2(1H)-0ne 
• 85931-92-6 4-methoxyimino-5-fluoro-5,6-dihydro-6-methoxyaminopyrimidin-2(1H)-one 
• 155-15-7 1-methyl-5-fluorocytosine 

Relevant articles and documents

Glorination of Pyrimidines. Part 2. Mechanistic Aspects of the Reaction of Acetyl Hypofluorite with Uracil and Cytosine Derivatives

The reaction of acetyl hypofluorite (AcOF) with uracil, cytosine, and some N-1-substituted derivatives dissolved in either acetic acid or water has been investigated.Analysis by radio-h.p.l.c., using (18)f as a tracer, and by (1)H n.m.r. revealed that a substituent at N-1 of uracil has a remarkable effect on the stability of the intermediate 6-acetoxy-5-fluoro-5,6-dihydrouracils.In addition, it was found that these cytosine adducts rapidly deaminate in water yielding their corresponding uracil analogues.