130277-16-6

Basic information

• Product Name: 2-Amino-3-benzylpyridine
• Synonyms: 2-Amino-3-benzylpyridine;3-(PhenylMethyl)-2-pyridinaMine
• CAS NO: 130277-16-6
• Molecular Formula: C₁₂H₁₂N₂
• Molecular Weight: 184.23708
• Product Categories: Amines;Aromatics;Heterocycles;Intermediates;Amines, Aromatics, Heterocycles, Intermediates
• Mol File: 130277-16-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 343.8±27.0 °C(Predicted)
• Appearance: /
• Density: 1.121±0.06 g/cm3(Predicted)
• Solubility: Dichloromethane, Methanol
• PKA: 7.11±0.36(Predicted)
• CAS DataBase Reference: 2-Amino-3-benzylpyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-3-benzylpyridine(130277-16-6)
• EPA Substance Registry System: 2-Amino-3-benzylpyridine(130277-16-6)

Safety Data

• Hazardous Substances Data: 130277-16-6(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Solid

Uses

Intermediate in the preparation of azepine derivatives

Upstream product

• 620-95-1 3-benzylpyridine 
• 153230-22-9 N-(3-Benzyl-2-pyridyl)carbamidsaeureethylester 
• 100-52-7 benzaldehyde 
• 80100-23-8 (2-chloropyridin-3-yl)(phenyl)methanol 
• 80099-81-6 3-benzoyl-2-chloro-pyridine 
• 109-09-1 2-chloropyridine 
• 153230-23-0 1-(3-Benzyl-2-pyridylaminocarbonyl)-4-methyl-piperazin 
• 3810-10-4 2-amino-3-benzoylpyridine 

Downstream Products

• 153230-22-9 N-(3-Benzyl-2-pyridyl)carbamidsaeureethylester 
• 61337-67-5 (-)-Mirtazapine 
• 61337-87-9 (+)-Mirtazapine 
• 85650-52-8 Mirtazapine 
• 1071504-77-2 (S)-(+)-10,11-dihydro-5H-benzo[e]pyrido[2,3-b]azepine-10-N-methylcarboxamide (+)-(S)-mandelic acid salt 
• 1071504-81-8 N-(2-hydroxyethyl)-N-methyl-10,11-dihydro-5H-benzo[e]pyrido[2,3-b]azepine-10-carboxamide 
• 191546-96-0 3,4,10,14b-tetrahydro-2-methyl-pyrazino[2,1-a]pyrido[2,3-c][2]benzazepin-1(2H)-one 
• 1071504-75-0 10,11-dihydro-5H-benzo[e]pyrido[2,3-b]azepine-10-carboxylic acid ethyl ester 
• 155405-66-6 N-(3-Benzyl-2-pyridyl)dibenzamid 
• 155405-68-8 2-Chlor-N-(2-chlorbenzoyl)-N-(3-benzyl-2-pyridyl)benzamid 
• 155405-72-4 2-Chlor-N-(3-benzyl-2-pyridyl)benzamid 
• 155405-70-2 N-(3-Benzyl-2-pyridyl)benzamid 

Relevant articles and documents

2-(Dimethylaminomethyl)-tetrahydroisoxazolopyridobenzazepine derivatives. Synthesis of a new 5-HT(2C) antagonist with potential anxiolytic properties.

Following the program started at Johnson & Johnson Pharmaceutical Research & Development searching for 5-HT(2A/2C) antagonists, we now report on the synthesis of 2-(dimethylaminomethyl)-2,3,3a,8-tetrahydroisoxazolo[3,2-a]pyrido[3,4-c]-[2]benzazepine and 2-(dimethylaminomethyl)-2,3,3a,8-tetrahydroisoxazolo[3,2-a]pyrido[3,2-c]-[2]benzazepine. A new method for the synthesis of pyridobenzazepines is described as well. The affinities for several receptors as well as the mCPP antagonistic activity of the compounds synthesised are described.

Synthesis of 10-(N'-methylpiperazino)-5H-pyrido[2,3-c]-2-benzazepine ('azaperlapine')

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A Bisubstrate Reaction Template

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