130285-75-5Relevant academic research and scientific papers
Polystyryl-BEMP as an efficient recyclable catalyst for the nucleophilic addition of nitroalkanes to α,β-unsaturated carbonyl compounds under solvent-free conditions
Ballini,Barboni,Castrica,Fringuelli,Lanari,Pizzo,Vaccarob
supporting information; experimental part, p. 1218 - 1224 (2009/05/30)
2-tert-Butylimino-2-diethylamino-1,3-dimethylperhydro-1,3, 2-diazaphosphorine supported on polystyrene (PS-BEMP) is an efficient catalyst for the addition of nitroalkanes (1-1.5 equiv.) to α,β-unsaturated carbonyl compounds (1.0 equiv.) in the absence of a reaction medium (solvent-free conditions). The corresponding γ-nitro carbonyl compounds have been isolated in excellent yields but the catalyst can be satisfactorily recovered and used for only 3 times due to the magnetic stirring which caused crunching of the catalyst beads thus hampering its complete recovery. To optimize the catalyst's reuse and improve the environmental efficacy of solvent-free conditions, the first solvent-free cyclic continuous-flow reactor has been set up. This reactor has allowed the product to be isolated in an almost quantitative yield by using a very small amount of organic solvent, making the recovery and reuse of the catalyst efficient and reproducible.
Synthesis of some isoxazole analogues of retinoids: biological effects toward tumor cell lines
Baraldi, P. G.,Guarneri, M.,Manfredini, S.,Simoni, D.,Tabrizi, M. Aghazade,et al.
, p. 279 - 284 (2007/10/02)
A series of isoxazole analogues of retinoids have been prepared.The in vitro biological activity of these compounds on different lineages of tumor cells is reported.Some of the prepared derivatives exibited good antiproliferative activity and capability t
