130288-91-4 Usage
Description
Piperazine, 1-(3-thienylmethyl)(9CI) is a chemical compound belonging to the piperazine group, which are organic compounds characterized by a six-membered piperazine ring with two nitrogen atoms and four carbon atoms. This particular compound features a 1-(3-thienylmethyl) group, which is a sulfur-containing thienyl ring, a methylated analog of a phenyl ring, attached to the piperazine ring. The 9CI notation indicates that this compound is recorded in the ninth collective index, serving as a reference identifier in chemical literature.
Uses
Used in Pharmaceutical Industry:
Piperazine, 1-(3-thienylmethyl)(9CI) is used as a pharmaceutical compound for its potential applications in the development of drugs. The presence of the thienyl ring and its methylation may contribute to the compound's bioactivity, making it a candidate for various therapeutic applications.
Used in Chemical Research:
Piperazine, 1-(3-thienylmethyl)(9CI) is used as a research chemical for studying the properties and reactions of piperazine derivatives. The unique structure of this compound, with its thienyl ring, can provide insights into the reactivity and potential applications of similar compounds in various chemical processes.
Used in Industrial Applications:
Piperazine, 1-(3-thienylmethyl)(9CI) is used as an industrial chemical for its potential role in the synthesis of various products. Piperazine, 1-(3-thienylmethyl)(9CI)'s structure may be utilized in the production of intermediates or final products in the chemical industry, depending on its reactivity and stability.
Check Digit Verification of cas no
The CAS Registry Mumber 130288-91-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,0,2,8 and 8 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 130288-91:
(8*1)+(7*3)+(6*0)+(5*2)+(4*8)+(3*8)+(2*9)+(1*1)=114
114 % 10 = 4
So 130288-91-4 is a valid CAS Registry Number.
InChI:InChI=1/C9H14N2S/c1-6-12-8-9(1)7-11-4-2-10-3-5-11/h1,6,8,10H,2-5,7H2
130288-91-4Relevant articles and documents
Design, synthesis and SAR of antitubercular benzylpiperazine ureas
Satish, Sohal,Chitral, Rohan,Kori, Amitkumar,Sharma, Basantkumar,Puttur, Jayashree,Khan, Afreen A.,Desle, Deepali,Raikuvar, Kavita,Korkegian, Aaron,Martis, Elvis A. F.,Iyer, Krishna R.,Coutinho, Evans C.,Parish, Tanya,Nandan, Santosh
, p. 73 - 96 (2021/01/04)
Abstract: N-furfuryl piperazine ureas disclosed by scientists at GSK Tres Cantos were chosen as antimycobacterial hits from a phenotypic whole-cell screen. Bioisosteric replacement of the furan ring in the GSK Tres Cantos molecules with a phenyl ring led to molecule (I) with an MIC of 1?μM against Mtb H37Rv, low cellular toxicity (HepG2 IC50 ~ 80?μM), good DMPK properties and specificity for Mtb. With the aim of delineating the SAR associated with (I), fifty-five analogs were synthesized and screened against Mtb. The SAR suggests that the piperazine ring, benzyl urea and piperonyl moieties are essential signatures of this series. Active compounds in this series are metabolically stable, have low cellular toxicity and are valuable leads for optimization. Molecular docking suggests these molecules occupy the Q0 site of QcrB like Q203. Graphic Abstract: Bioisosteric replacement of N-furfuryl piperazine-1-carboxamides yielded molecule (I) a novel lead with satisfactory PD, metabolism, and toxicity profiles.[Figure not available: see fulltext.]
