130289-80-4

Basic information

• Product Name: 1-(1H-indol-3-yl)-2-(4-methoxyphenyl)ethane-1,2-dione
• Synonyms: 1-(1H-indol-3-yl)-2-(4-methoxyphenyl)ethane-1,2-dione
• CAS NO: 130289-80-4
• Molecular Weight: 279.295
• Mol File: 130289-80-4.mol

Chemical Properties

• CAS DataBase Reference: 1-(1H-indol-3-yl)-2-(4-methoxyphenyl)ethane-1,2-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(1H-indol-3-yl)-2-(4-methoxyphenyl)ethane-1,2-dione(130289-80-4)
• EPA Substance Registry System: 1-(1H-indol-3-yl)-2-(4-methoxyphenyl)ethane-1,2-dione(130289-80-4)

Safety Data

• Hazardous Substances Data: 130289-80-4(Hazardous Substances Data)

Upstream product

• 120-72-9 indole 
• 6037-64-5 1-(4-methoxyphenyl)-2-(phenylamino)ethane-1-one 
• 75681-30-0 1-(4-methoxyphenyl)-2-(methyl(phenyl)amino)ethan-1-one 
• 1076-95-5 p-methoxyphenylglyoxal 

Relevant articles and documents

Synthesis of 3-acylated indoles through iron-catalyzed oxidative coupling of indoles with α-amino carbonyl compounds

A novel iron-catalyzed oxidative coupling of indoles with α-amino carbonyl compounds has been developed. The transformation provides an attractive approach to the synthesis of 3-acylindoles, with the advantages of easily available starting materials and high functional group tolerance. Furthermore, control experiments imply that a radical process maybe involved in this reaction.

A Regioselective Approach to Synthesize Indolyl Diketone Derivatives via Magnetic Polymeric Copper-Catalyst

Abstract: In the present paper, an efficient Cu-catalyzed regioselective acylation of indoles with phenylglyoxals was developed which is the first example of indolyl diketones synthesis by a heterogeneous catalyst. The magnetic polyacrylonitrile was synth

Copper-catalyzed synthesis of indolyl diketones: Via C-H oxidation/diacylation of indoles with arylglyoxal hydrates

An expedient protocol for Cu-catalyzed C-H oxidation/diacylation of indoles with arylglyoxal hydrates to construct indolyl diketones is developed. This methodology exhibits the synthetic utility of the synthesis of an indole-alkaloid 1,2-di(1H-indol-3-yl)ethane-1,2-dione and offers a straightforward means to produce different indolyl nitrogen-containing heterocycles such as indolyl quinoxaline, indolyl hydantoin and indolyl imidazole in high yields. Preliminary mechanistic studies indicate that two proposed pathways are involved in this process.

3-dicarbonyl substitution indole compound and preparation method thereof

The invention discloses a 3-dicarbonyl substitution indole compound and a preparation method thereof, and belongs to the technical field of synthesis of indole derivatives. According to the technical scheme, the 3-dicarbonyl substitution indole compound i

Aminocatalytic cross-coupling approach via iminium ions to different C-C bonds

Given the attractive ability of iminium ions to functionalize molecules directly at ostensibly unreactive positions, the reactivity of iminium ions, in which an α CH2 group is replaced by C=O was explored. Background studies on the ability of such iminium cations to promote reactions via an iminium-catalyzed or iminium-equivalent pathway are apparently unavailable. Previously, tandem cross-coupling reactions were reported, in which an iminium ion undergoes nucleophilic 1,2-addition to give a putative three-component intermediate that abstracts a proton in situ and undergoes self-deamination followed by unprecedented DMSO/ aerobic oxidation to generate a-ketoamides. However, later it was observed that iminium ions can generate valuable α-ketoamides through simple aerobic oxidation. In all reactions, iminium ions were generated in situ by reaction of 2-oxoaldehydes with secondary amines.

Palladium-catalyzed synthesis of 3-acylated indoles involving oxidative cross-coupling of indoles with α-amino carbonyl compounds

A new and selective C-N bond oxidative cleavage method to 3-acylated indoles by Pd-catalyzed oxidative cross coupling of indoles with α-amino carbonyl compounds has been developed; moreover, one-pot synthesis of 3-acylated indoles from 2-ethynylanilines and α-amino carbonyl compounds has also been established. Importantly, the products 3-acylated indoles can be used to construct polyheterocyclic compound, which can be employed as efficient probes for Hg2+ and Fe3+.

Copper-catalyzed C-H oxidation/cross-coupling of α-amino carbonyl compounds

Keeping options open: The new and mild title reaction involving indoles selectively furnishes 1 and 2 with the aid of tert-butyl hydroperoxide (TBHP). The method represents the first example of a copper-catalyzed α arylation of α-amino carbonyl substrates leading to α-aryl α-imino and α-aryl α-oxo carbonyl compounds using a C-H oxidation strategy. Copyright