130305-18-9

Upstream product

• 130305-16-7 2-acetoxymethyl-3,4-difluoronitrobenzene 
• 87-13-8 diethyl 2-ethoxymethylenemalonate 
• 144298-16-8 (6-amino-2,3-difluorophenyl)methanol 
• 108-24-7 acetic anhydride 
• 144298-19-1 Diethyl (3,4-difluoro-2-hydroxymethylanilinyl)methylidenemalonate 
• 144298-14-6 (3,4-Difluoro-2-hydroxymethyl-phenyl)-carbamic acid tert-butyl ester 
• 144298-09-9 2,3-Difluoro-6-(tert-butoxycarbamoyl)benzaldehyde 

Relevant academic research and scientific papers

A practical route to C-8 substituted fluoroquinolones

The ortho metalation of N-(tert-butoxycarbonyl)-3,4-difluoroaniline, with t-BuLi at -78°C in THF occurred regioselectively at C-2 position. The resulting lithiated species reacted with a variety of electrophiles to give 2-substituted-3,4-difluoranilines i

Novel pyridobenzoxazine derivative

Pyridobenzoxazine derivatives having a [3,2,1--ij][3,1]benzoxazine structure represented by the formula (I) and their salts are disclosed. There are many varieties for the compound depending on the types of residues R1-R4, X1, and X2. The compounds of formula (I) and their salts have excellent antimicrobial activities and wide antimicrobial spectra, and are effective against both gram positive and gram negative microorganisms. They can be used as a medicine, an agrichemical, and a food preservative.