1303516-04-2Relevant articles and documents
On the synthesis of conformationally modified peptides through isonitrile chemistry: Implications for dealing with polypeptide aggregation
Wu, Xiangyang,Park, Peter K.,Danishefsky, Samuel J.
, p. 7700 - 7703 (2011/07/31)
A method for introducing a dimethyleneoxy constraint joining the N atoms of two consecutive amino acids in the context of a polypeptide has been developed. This constraint can profoundly affect the tendency of a polypeptide to suffer aggregation and desolubilization, and it can be readily removed under mild conditions.
