1303576-89-7

Upstream product

• 80500-27-2 (4-methyl-3-nitrophenyl)boronic acid 
• 707-60-8 4-bromo-N,N-dimethylbenzenesulfonamide 
• 1303573-58-1 N,N,4'-trimethyl-3'-nitrobiphenyl-4-sulfonamide 
• 1303575-26-9 C₁₈H₁₈N₂O₇S 

Downstream Products

• 1303572-01-1 6-(4-(N,N-dimethylsulfamoyl)phenyl)-1-hydroxy-1H-indole-2-carboxylic acid 

Relevant academic research and scientific papers

Synthesis of sulfonamide-containing N-hydroxyindole-2-carboxylates as inhibitors of human lactate dehydrogenase-isoform 5

N-Hydroxyindole-2-carboxylates possessing sulfonamide-substituents at either position 5 or 6 were designed and synthesized. The inhibitory activities of these compounds against isoforms 1 and 5 of human lactate dehydrogenase were analysed, and Ki values of the most efficient inhibitors were determined by standard enzyme kinetic studies. Some of these compounds displayed state-of-the-art inhibitory potencies against isoform 5 (Ki values as low as 5.6 μM) and behaved as competitive inhibitors versus both the substrate and the cofactor.