130378-65-3

Upstream product

• 92151-73-0 2-phenylethynylphenol 
• 100-09-4 4-methoxybenzoic acid 

Downstream Products

• 130378-68-6 2-[4-(2-pyrrolidinoethoxy)phenyl]-3-phenyl-4H-1-benzopyran-4-one 
• 130378-67-5 2-(4-hydroxyphenyl)-3-phenyl-4H-1-benzopyran-4-one 
• 130378-66-4 2-(4-methoxyphenyl)-3-phenyl-4H-1-benzopyran-4-one 

Relevant academic research and scientific papers

Iridium(i)-catalyzed hydration/esterification of 2-alkynylphenols and carboxylic acids

An iridium(i)-catalyzed hydration/esterification of 2-alkynylphenols and carboxylic acids is described. Various 2-alkynylphenols and carboxylic acids could be used in this process to furnish aromatic ortho-acyloxyketones via a regio- and stereo-selective addition reaction followed by intramolecular rearrangement. This protocol features mild reaction conditions and broad substrate scope. Further transformations were conducted to demonstrate the synthetic application.