1303974-65-3 Usage
General Description
1-(tert-butoxycarbonyl)-4,4-difluoropiperidine-3-carboxylic acid is a chemical compound with a complex structure that includes a piperidine ring and a carboxylic acid group. The presence of the tert-butoxycarbonyl group indicates that the compound is likely a protected amino acid derivative, often used in organic synthesis to protect and manipulate specific functional groups. The difluoro substitution on the piperidine ring indicates the presence of two fluorine atoms, which can alter the reactivity and properties of the compound. Overall, this compound likely has uses in organic synthesis, pharmaceutical research, and other chemical applications due to its unique structure and functional groups.
Check Digit Verification of cas no
The CAS Registry Mumber 1303974-65-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,0,3,9,7 and 4 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1303974-65:
(9*1)+(8*3)+(7*0)+(6*3)+(5*9)+(4*7)+(3*4)+(2*6)+(1*5)=153
153 % 10 = 3
So 1303974-65-3 is a valid CAS Registry Number.
1303974-65-3Relevant articles and documents
Semi-Industrial Fluorination of β-Keto Esters with SF 4: Safety vs Efficacy
Bugera, Maksym Y.,Khairulin, Andrii R.,Kliukovskyi, Denys V.,Ryabukhin, Sergey V.,Semenov, Sergey V.,Shevchenko, Valerii O.,Tarasenko, Karen V.,Trofymchuk, Serhii A.,Volochnyuk, Dmitriy M.
, p. 565 - 574 (2020/03/27)
The possibility of deoxofluorination of β-keto esters using SF 4 was investigated. The scope and limitation of the reaction were determined. The efficient method for the synthesis of β,β-difluorocarboxylic acids was elaborated based on the reaction. The set of mentioned acids, being the perspective building blocks for medicinal chemistry, were synthesized on multigram scale. The safety of SF 4 use was discussed. The described method does not improve upon the safety of using SF 4, but practical recommendations for working with the reagent are proposed. Despite the hazards of using toxic SF 4, a significant increase of efficacy in the synthesis of medicinal-chemistry-relevant building blocks, based on the reaction, in comparison with earlier described approaches is shown.