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Bismuth subnitrate, also referred to as bismuth oxynitrate or bismuthyl nitrate, is a highly water-soluble crystalline compound that has been used as a treatment for duodenal ulcers and anti-diarrheic agent. The use of bismuth substrate as an active ingredient in over-the-counter antacids is approved by the FDA. Bismuth Subnitrate is a basic salt that contains the equivalent of not less than 79.0 percent of bismuth trioxide (Bi2O3),calculated on the dried basis.It is both odorless and tasteless, and is used in bleaching and freckle creams, and hair dyes. Bismuth subnitrate has been used to induce metallothionein in heart tissue and kidneys and to attenuate the toxicity of Adriamycin and cisplatin compounds, respectively.

1304-85-4

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1304-85-4 Usage

Chemical Properties

White, heavy, Slightly hygroscopic powder

Uses

Different sources of media describe the Uses of 1304-85-4 differently. You can refer to the following data:
1. manufacture of bismuth fluxes for enamels; in cosmetics.
2. It is used pharmaceutically in wound dressing, ointment component and as an antiacid. In cosmetics it is used as a cosmetic white pigment. Used in Ceramic glazes and enamel fluxes.
3. Bismuth subnitrate (BiNO3) is used in the cosmetics industry and to make ceramic and enamel glazes.

Brand name

Mammol (Abbott).

Flammability and Explosibility

Nonflammable

Pharmacology

Bismuth subnitrate acts as an antacid that exert protective effects on the gastric mucosa. In a double-blind endoscopically controlled study, bismuth substrate was demonstrated to be effective for symptomatic relief in duodenal ulcers. In the alcohol model of mucosal injury in the rat, bismuth substrate was shown to be cytoprotective. In a randomized clinical study consisting of patients with H. pylori-associated duodenal ulcer, adjunctive use of colloidal bismuth subnitrate in a short treatment regimen with omeprazole and clarithromycin resulted in improved eradication rate of H. pylori.

Mode of action

Based on the findings of a clinical investigation in patients with duodenal ulcer disease and healthy volunteers receiving oral bismuth subnitrate tablets, the protective effects of bismuth subnitrate may be secondary to endogenous mucosal prostaglandin (PGE2) production, which is one of the deficient factors observed in peptic ulcer disease. Antacid neutralizing activity of bismuth subnitrate was demonstrated to have a significant postprandial effect on gastric pH.

Check Digit Verification of cas no

The CAS Registry Mumber 1304-85-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,3,0 and 4 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1304-85:
(6*1)+(5*3)+(4*0)+(3*4)+(2*8)+(1*5)=54
54 % 10 = 4
So 1304-85-4 is a valid CAS Registry Number.
InChI:InChI=1/Bi.NO3.O/c;2-1(3)4;/q+3;-1;-2

1304-85-4 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail

  • Alfa Aesar

  • (40476)  Bismuth hydroxide nitrate oxide, Bi2O3 79% min   

  • 1304-85-4

  • 25g

  • 196.0CNY

  • Detail

  • Alfa Aesar

  • (40476)  Bismuth hydroxide nitrate oxide, Bi2O3 79% min   

  • 1304-85-4

  • 100g

  • 581.0CNY

  • Detail

  • Alfa Aesar

  • (40476)  Bismuth hydroxide nitrate oxide, Bi2O3 79% min   

  • 1304-85-4

  • 500g

  • 1979.0CNY

  • Detail

  • Sigma-Aldrich

  • (10334)  Bismuth(III)subnitrate  puriss., meets analytical specification of USP, 71-74% Bi basis (calc. on dried substance)

  • 1304-85-4

  • 10334-1KG-R

  • 2,760.03CNY

  • Detail

  • Sigma-Aldrich

  • (310646)  Bismuth(III)subnitrate  98%

  • 1304-85-4

  • 310646-5G

  • 593.19CNY

  • Detail

  • Sigma-Aldrich

  • (310646)  Bismuth(III)subnitrate  98%

  • 1304-85-4

  • 310646-100G

  • 785.07CNY

  • Detail

  • Sigma-Aldrich

  • (310646)  Bismuth(III)subnitrate  98%

  • 1304-85-4

  • 310646-500G

  • 2,995.20CNY

  • Detail

  • USP

  • (1075644)  Bismuthsubnitrate  United States Pharmacopeia (USP) Reference Standard

  • 1304-85-4

  • 1075644-1.5G

  • 4,326.66CNY

  • Detail

1304-85-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name Bismuth hydroxide nitrate oxide

1.2 Other means of identification

Product number -
Other names Bismuth(III) subnitrate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1304-85-4 SDS

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