130408-77-4 Usage
Uses
A-71623 is a potent CCK agonist with 1200-fold selectivity over the CCK2 receptor.
Biological Activity
Potent CCK 1 agonist (IC 50 = 3.7 nM) with 1200-fold selectivity over the CCK 2 receptor. Suppresses food intake following central or peripheral administration.
references
[1]. gracey dj, bell r, king dj. differential effects of the ccka receptor ligands pd-140,548 and a-71623 on latent inhibition in the rat. progress in neuro-psychopharmacology and biological psychiatry, 2002, 26(3): 497-504.[2]. lin cw, shiosaki k, miller tr, et al. characterization of two novel cholecystokinin tetrapeptide (30-33) analogues, a-71623 and a-70874, that exhibit high potency and selectivity for cholecystokinin-a receptors. molecular pharmacology, 1991, 39(3): 346-351.[3]. kaufmann r, lindschau c, scho t, et al. type b cholecystokinin receptors on rat glioma c6 cells. binding studies and measurement of intracellular calcium mobilization. brain research, 1994, 639(1): 109-114.
Check Digit Verification of cas no
The CAS Registry Mumber 130408-77-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,0,4,0 and 8 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 130408-77:
(8*1)+(7*3)+(6*0)+(5*4)+(4*0)+(3*8)+(2*7)+(1*7)=94
94 % 10 = 4
So 130408-77-4 is a valid CAS Registry Number.
InChI:InChI=1/C44H56N8O9/c1-27-15-9-11-19-31(27)50-42(59)46-22-14-13-21-33(39(56)49-35(25-37(53)54)41(58)52(5)36(38(45)55)23-28-16-7-6-8-17-28)48-40(57)34(51-43(60)61-44(2,3)4)24-29-26-47-32-20-12-10-18-30(29)32/h6-12,15-20,26,33-36,47H,13-14,21-25H2,1-5H3,(H2,45,55)(H,48,57)(H,49,56)(H,51,60)(H,53,54)(H2,46,50,59)/t33-,34-,35-,36-/m0/s1
130408-77-4Relevant articles and documents
Tetrapeptide CCK Agonists: Structure-Activity Studies on Modifications at the N-Terminus
Elliott, Richard L.,Kopecka, Hana,Bennett, Michael J.,Shue, Youe-Kong,Craig, Richard,et al.
, p. 309 - 313 (2007/10/02)
We had reported earlier on a novel series of potent and selective tetrapeptide cholecystokinin-A (CCK-A) agonists of the general structure Boc-Trp-Lys-Asp-N(R)PheNH2 that were potent anorectic agents in rats.In an effor
