1304127-09-0Relevant articles and documents
Highly enantioselective synthesis of fluorinated β-amino ketones via asymmetric organocatalytic Mannich reactions: A case study of unusual reversal of regioselectivity
Lu, Min,Lu, Yunpeng,Tan, Puay Kah Amy,Lau, Qiu Ying,Zhong, Guofu
, p. 477 - 480 (2011)
The highly enantioselective direct Mannich protocol employing fluoroacetone, p-anisidine, and aldehydes catalyzed by 4-siloxyproline was developed, allowing efficient access for pharmaceutically important fluorinated β-amino ketones. On the basis of DFT c