13042-18-7

Basic information

• Product Name: Fendiline
• Synonyms: N-(1-Phenylethyl)-3,3-diphenylpropylamine;3,3-diphenyl-N-(1-phenylethyl)propan-1-amine
• CAS NO: 13042-18-7
• Molecular Formula: C₂₃H₂₅N
• Molecular Weight: 315.45
• EINECS: 235-915-6
• Mol File: 13042-18-7.mol
• Article Data: 22

Chemical Properties

• Boiling Point: bp0.3 206-210°
• Flash Point: 207.9°C
• Appearance: /
• Density: 1.031g/cm³
• Vapor Pressure: 2.3E-08mmHg at 25°C
• Refractive Index: 1.582
• Water Solubility: 2.331mg/L(22.5 oC)
• CAS DataBase Reference: Fendiline(CAS DataBase Reference)
• NIST Chemistry Reference: Fendiline(13042-18-7)
• EPA Substance Registry System: Fendiline(13042-18-7)

Safety Data

• Hazardous Substances Data: 13042-18-7(Hazardous Substances Data)

Usage

Originator

Sensit,Thiemann,W. Germany,1974

Manufacturing Process

21.13 grams of γ,γ-diphenyl-propylamine and 12.01 grams of acetophenone are hydrogenated in 200 ml of methanol at 55°C and a pressure of 10 atmospheres in the presence of palladium charcoal. On filtration of the catalyst the solution is concentrated and the remainder is distilled in vacuo at a pressure of 0.3 Hg mm. The main distillate is collected at 206° to 210°C. 25.38 grams of N-[1'-phenylethyl-(1')]-1,1-diphenyl-propyl-(3)-amine are obtained.The product is dissolved in 134 ml of 96% ethanol whereupon 26.8 ml of concentrated hydrochloric acid and 201 ml of water are added while cooling with ice-water. The precipitate is filtered off and dried in vacuo at 100°C. 22.98 grams of N-[1'-phenylethyl)-(1')]-1,1-diphenyl-propyl-(3)-amine hydrochloride are obtained. MP 200° to 201°C. On recrystallization from 285 ml of a 2:1 mixture of water and 96% ethanol the melting point remains unchanged.

Therapeutic Function

Coronary vasodilator

InChI:InChI=1/C23H25N/c1-19(20-11-5-2-6-12-20)24-18-17-23(21-13-7-3-8-14-21)22-15-9-4-10-16-22/h2-16,19,23-24H,17-18H2,1H3

Upstream product

• 20017-67-8 3,3-diphenylpropan-1-ol 
• 618-36-0 rac-methylbenzylamine 
• 4279-81-6 3,3-diphenylpropanal 
• 100938-80-5 N-(3,3-diphenylpropyl)benzamide 
• 917-54-4 methyllithium 
• 1377583-19-1 tert-butyl (3,3-diphenylpropyl)carbamate 
• 585-71-7 (1-bromoethyl)benzne 
• 5586-73-2 3-diphenylpropyl amine 
• 98-86-2 acetophenone 
• 530-48-3 1,1-Diphenylethylene 
• 23808-47-1 3,3-diphenylpropyl 4-methylbenzenesulfonate 
• 4279-86-1 3,3-diphenyl-1-propyne 
• 59576-43-1 3,3-Diphenyl-N-(1-phenyl-ethyl)-propionamide 
• 201230-82-2 carbon monoxide 

Downstream Products

• 13042-18-7 Fendiline 
• 1004290-89-4 fendiline-diazeniumdiolate 
• 1019-05-2 3,3-diphenyl-propylamine; hydrochloride 
• 108393-62-0 (+)-Fendiline 

Related news

Full PapersFrequency- and Time-Dependent Effects of Fendiline (cas 13042-18-7) on Action Potentials of Guinea Pig Papillary Muscle09/26/2019

ABSTRACTThe action of fendiline on cardiac electrical activity was investigated in guinea pig papillary muscle by monitoring frequency- and time-dependent changes in membrane potential, action potential (AP) configuration and conduction velocity. Isolated guinea pig papillary muscles driven at 0...detailed

Fendiline (cas 13042-18-7) increases [Ca2+]i in Madin Darby canine kidney (MDCK) cells by releasing internal Ca2+ followed by capacitative Ca2+ entry09/25/2019

The effect of fendiline, a documented inhibitor of L-type Ca2+ channels and calmodulin, on Ca2+ signaling in Madin Darby canine kidney (MDCK) cells was investigated using fura-2 as a Ca2+ probe. Fendiline at 5–100 μM significantly increased [Ca2+]i concentration-dependently. The [Ca2+]i rise c...detailed

The anti-anginal drug Fendiline (cas 13042-18-7) increases intracellular Ca2+ levels in MG63 human osteosarcoma cells09/24/2019

The effect of fendiline, an anti-anginal drug, on cytosolic free Ca2+ levels ([Ca2+]i) in MG63 human osteosarcoma cells was explored by using fura-2 as a Ca2+ indicator. Fendiline at concentrations between 1 and 200 μM increased [Ca2+]i in a concentration-dependent manner and the signal saturat...detailed

The anti-anginal drug Fendiline (cas 13042-18-7) elevates cytosolic Ca2+ in rabbit corneal epithelial cells09/10/2019

The effect of the anti-anginal drug fendiline on intracellular free Ca2+ levels ([Ca2+]i) in a rabbit corneal epithelial cell line (SIRC) was explored using fura-2 as a fluorescent Ca2+ indicator. At a concentration above 1 μM, fendiline increased [Ca2+]i in a concentration-dependent manner wit...detailed

Determination of Fendiline (cas 13042-18-7) and gallopamil by capillary isotachophoresis09/09/2019

Capillary isotachophoresis was applied for the determination of fendiline and gallopamil – calcium antagonists – in serum. The cationic electrolyte system containing Na+ with acetic acid as a counter constituent was used as a leading electrolyte with the pH 4.7 and the terminating electrolyte ...detailed

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