13045-22-2

Upstream product

• 937-30-4 4-ethylacetophenone 
• 1779-49-3 Methyltriphenylphosphonium bromide 

Downstream Products

• 1071629-12-3 4-(4-ethyl-phenyl)-2-hydroxy-2-trifluoromethyl-pent-4-enoic acid ethyl ester 
• 1402166-88-4 (E)-1-ethyl-4-(1-nitroprop-1-en-2-yl)benzene 
• 1402167-00-3 1-ethyl-4-(1-nitropropan-2-yl)benzene 
• 1448781-94-9 ((3R,5R)-5-(4-ethylphenyl)-3-isobutyl-5-methylpyrazolidin-1-yl)(4-nitrophenyl)methanone 
• 937-30-4 4-ethylacetophenone 

Relevant academic research and scientific papers

Palladium/Acid Relay Catalyzed Tandem Heck Coupling/6-Endo Cyclization between ortho-Halogenated Benzoates and Unactivated Terminal Alkenes for the Synthesis of 1-Isochromanones

We report a unique and expeditious route to synthesize 1-isochromanone derivatives through palladium catalyzed tandem Heck coupling/6-endo hydroacyloxylation cyclization between readily available ortho-halogenated benzoates and unactivated alkenes. Various 2-bromo or 2-iodo benzoates can be coupled efficiently with a broad range of alkenes to afford functionalized 1-isochromanones in high yields. Significantly, this cost-efficient and easy-to-handle synthetic methodology will have great prospect application in the synthetic and medicinal chemistry. (Figure presented.).

Highly enantioselective hydrogenation of β,β-disubstituted nitroalkenes

Building the building blocks: A highly enantioselective hydrogenation of ?-aryl-?-alkyl disubstituted nitroalkenes 1 has been developed. This method results in enantiomerically pure nitroalkanes 2, which are versatile precursors for chemical synthesis.