130451-91-1Relevant articles and documents
STEREOCHEMICAL STUDIES, 145. SATURATED HETEROCYCLES, 152. PREPARATION AND CONFORMATIONAL ANALYSIS OF STEREOISOMERIC 1,6,7,11b-TETRAHYDRO-2HOXAZINOISOQUINOLIN-4-ONE DERIVATIVES
Lazar, Laszlo,Fueloep, Ferenc,Dombi, Gyoergy,Bernath, Gabor,Argay, Gyula,Kalman, Alajos
, p. 4039 - 4048 (1990)
Starting from 1--6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline 3a, trifunctional 1,2,3,4-tetrahydroisoquinolines were synthetized.From the N-ethoxycarbonyl derivative of 3a, (r-11b,c-1)-1-hydroxymethyl- (8) and (r-11b,t-1)-1-chloromethyl-9,10-dimethoxy-1,6,7,11b-tetrahydro-2Hoxazinoisoquinolin-4-one (9) were formed in unexpected reactions.High-resolution NMR revealed that the tetrahydroisoquinoline-fused C-1 epimer oxazinone derivatives 8 and 9 have different conformations in solution.The first X-ray diffraction evidence of the presence of two different conformations of oxazinoisoquinolines 8 and 9 in the solid state is provided.