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Relevant academic research and scientific papers

Copper-catalyzed electrophilic amination of heteroarenes and arenes by C-H zincation

Direct amination of heteroarenes and arenes has been achieved in a one-pot C-H zincation/copper-catalyzed electrophilic amination procedure. This amination method provides an efficient and rapid approach to access a diverse range of heteroaromatic and aromatic amines including those previously inaccessible using C-H amination methods. The mild reaction conditions and good functional-group compatibility demonstrate its great potential for the synthesis of important and complex amines. Direct amination of heteroarenes and arenes has been achieved in a one-pot zincation/Cu(OAc)2-catalyzed amination sequence using O-acylhydroxylamines. The method provides a rapid and efficient approach to a range of aromatic and heteroaromatic amines, including those which were previously inaccessible by using C-H amination methods. tmp=2,2,6,6- tetramethylpiperidide.

Copper-catalyzed direct amination of polyfluoroarenes and azoles with hydroxylamines and its application to the synthesis of 3-aminobenzoheteroles

A copper-catalyzed electrophilic, umpolung amination strategy for the direct C-H amination of polyfluoroarenes and 1,3-azoles has been developed. The copper-based amination reaction is robust and can be easily scaled up on a gram scale. Its application to

Copper-catalyzed direct amination of electron-deficient arenes with hydroxylamines

The C-H amination of electron-deficient arenes such as polyfluoroarenes and azole compounds with O-acylated hydroxylamines effectively proceeds in the presence of a copper catalyst even at room temperature to provide the corresponding anilines and aminoaz