1304704-42-4Relevant academic research and scientific papers
Synthesis and antimicrobial activity of novel quinoline derivatives bearing pyrazoline and pyridine analogues
Desai, Nisheeth C.,Patel, Bonny Y.,Dave, Bharti P.
, p. 109 - 119 (2017/01/12)
The present investigation is in the interest of some synthesized novel derivatives containing (5-(2-chloroquinolin-3-yl)-3-(aryl)-4,5-dihydro-1H-pyrazol-1-yl)(pyridin-4-yl)methanones (4a–o) moieties incorporated with different biological active heterocycles such as quinoline, pyrazoline and pyridine derivatives. For the determination of the compounds reported in this paper was based on IR, 1H NMR, 13C NMR and mass spectral data and same compounds were screened for their antibacterial and antifungal activity on four bacteria (Staphylococcus aureus, Streptococcus pyogenes, Escherichia coli, Pseudomonas aeruginosa) and three fungi (Candida albicans, Aspergillus niger, Aspergillus clavatus) using ampicillin and griseofulvin as the standard drugs. Cytotoxicity study was carried out using MTT colorimetric assay (HeLa cell line). Among the screened compounds, 4e, 4f and 4n showed most potent antibacterial activity, while compounds 4d and 4g emerged as the most active against fungal strains. The results demonstrated that compound 4o was remarkably active against all microbial strains. From the viewpoint of SAR studies, it was observed that the presence of electron withdrawing groups remarkably enhanced the antimicrobial activity of synthesized compounds. Additionally, preliminary MTT cytotoxicity studies on HeLa cells suggested that effective antimicrobial activity of 4e–g, 4n and 4o was accompanied by low cytotoxicity.
Synthesis, characterization and antimicrobial screening of hybrid molecules containing quinoline, pyrimidine and morpholine analogues
Desai,Rajpara,Joshi,Vaghani,Satodiya
, p. 321 - 333 (2013/07/26)
In an attempt to find new bio-active molecules, a series of compounds N-(4-(2-chloroquinolin-3-yl)-6-(aryl)pyrimidin-2-yl)-2-morpholinoacetamides (5a-l) were synthesized by multistep reactions. Compounds were characterized by IR, NMR and mass spectra. Ant
Synthesis of quinoline-pyrazoline based thiazole derivatives endowed with antimicrobial activity
Desai,Joshi, Vivek V,Rajpara, Kiran M,Vaghani, Hasit V,Satodiya, Hitesh M
, p. 1191 - 1201 (2013/10/08)
A new series of 2-(5-(2-chloroquinolin-3-yl)-3-(aryl)-4,5-dihydro-1H- pyrazol-1-yl)thiazol-4(5H)ones 4a-l have been prepared and characterized by IR, NMR and mass spectroscopy. The synthesized compounds have been screened for antimicrobial activity agains
Benign methodology and improved synthesis of 5-(2-chloroquinolin-3-yl)-3- phenyl-4,5-dihydroisoxazoline using acetic acid aqueous solution under ultrasound irradiation
Tiwari, Vandana,Parvez, Ali,Meshram, Jyotsna
experimental part, p. 911 - 916 (2012/03/08)
In the present paper, we have executed the synthesis of substituted 5-(2-chloroquinolin-3-yl)-3-phenyl-4,5-dihydroisoxazolines via the reactions of substituted 3-(2-chloroquinolin-3-yl)-1-phenylprop-2-en-1-ones with hydroxylamine hydrochloride and sodium
Novel oxazine skeletons as potential antiplasmodial active ingredients: Synthesis, in vitro and in vivo biology of some oxazine entities produced via cyclization of novel chalcone intermediates
Tiwari, Vandana,Meshram, Jyotsna,Ali, Parvez,Sheikh, Javed,Tripathi, Umanath
experimental part, p. 569 - 578 (2012/06/01)
A novel series of 6-(2-chloroquinolin-3-yl)-4-substituted-phenyl-6H-1,3- oxazin-2-amines were synthesized and evaluated for in vitro antimalarial efficacy against chloroquine sensitive (MRC-02) as well as chloroquine resistant (RKL9) strains of Plasmodium
