1304778-15-1Relevant articles and documents
Identification of potent, noncovalent fatty acid amide hydrolase (FAAH) inhibitors
Gustin, Darin J.,Ma, Zhihua,Min, Xiaoshan,Li, Yihong,Hedberg, Christine,Guimaraes, Cris,Porter, Amy C.,Lindstrom, Michelle,Lester-Zeiner, Dianna,Xu, Guifen,Carlson, Timothy J.,Xiao, Shouhua,Meleza, Cesar,Connors, Richard,Wang, Zhulun,Kayser, Frank
, p. 2492 - 2496 (2011/05/15)
Starting from a series of ureas that were determined to be mechanism-based inhibitors of FAAH, several spirocyclic ureas and lactams were designed and synthesized. These efforts identified a series of novel, noncovalent FAAH inhibitors with in vitro potency comparable to known covalent FAAH inhibitors. The mechanism of action for these compounds was determined through a combination of SAR and co-crystallography with rat FAAH.
