130484-97-8

Basic information

• Product Name: 6-amino-1,2-dihydro-1-(4-methylphenyl)-2-oxo-3,5-pyridinedicarbonitrile
• Synonyms: 6-amino-1,2-dihydro-1-(4-methylphenyl)-2-oxo-3,5-pyridinedicarbonitrile
• CAS NO: 130484-97-8
• Molecular Weight: 250.26
• Mol File: 130484-97-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 6-amino-1,2-dihydro-1-(4-methylphenyl)-2-oxo-3,5-pyridinedicarbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 6-amino-1,2-dihydro-1-(4-methylphenyl)-2-oxo-3,5-pyridinedicarbonitrile(130484-97-8)
• EPA Substance Registry System: 6-amino-1,2-dihydro-1-(4-methylphenyl)-2-oxo-3,5-pyridinedicarbonitrile(130484-97-8)

Safety Data

• Hazardous Substances Data: 130484-97-8(Hazardous Substances Data)

Upstream product

• 6876-54-6 2-cyano-N-(4-methylphenyl)acetamide 
• 123-06-8 Ethoxymethylenemalononitrile 
• 106-49-0 p-toluidine 
• 130484-73-0 (2E,4E)-5-Amino-2,4-dicyano-5-p-tolylamino-penta-2,4-dienoic acid ethyl ester 
• 51767-89-6 4-chloro-7-methyl-5,7-diaza-1,3,5-octatriene-1,1,3-tricarbonitrile 
• 84655-66-3 6-<(dimethylamino)methyleneamino>-1,2-dihydro-2-imino-1-(4-methylphenyl)-3,5-pyridinedicarbonitrile 

Downstream Products

• 84655-70-9 6-<(dimethylamino)methyleneamino>-1,2-dihydro-1-(4-methylphenyl)-2-oxo-3,5-pyridinedicarbonitrile 

Relevant articles and documents

Competing transformations of 2-cyanoacetanilides in reactions with derivatives of ethoxymethylenemalonic acid

Ethoxymethylenemalonodinitrile 1B and ethyl ethoxymethylenecyanoacetate 1C in cyclocondensations with 2-cyanoacetanilides 2 behave as a three-carbon fragment transfer reagent to afford the corresponding 5-cyano-and 5-ethoxycarbonyl-6-amino-1-aryl-3-cyanopyridin-2(1H)-one derivatives 7B and 8C. One carbon transfer described earlier for such reactions with a use of diethyl 2-(ethoxymethylene)malonate 1A was observed only as a side process in the case of 1C leading to 2-amino-5-cyano-6-oxo-N,1-diaryl-1,6-dihydropyridine-3- carboxamides. ARKAT-USA, Inc.

Syntheses with Nitriles. 62. 3,5-Dicyanopyridine Derivatives by Vilsmeier Formylation of Malononitrile and Tetracyanopropenides (2)

Reaction of malononitrile with dimethylformamide and phosphorus oxychloride gave (dimethylaminomethylene)malononitrile (1), 4-chloro-7-methyl-5,7-diaza-1,3,5-octatriene-1,1,3-tricarbonitrile (3a) and the pyridine 2.Compounds 3a and 3b as well as the triaza-derivative 3c may also be obtained by treatment of tetracyanopropenides 4a-c with dimethylformamide and phosphorus oxychloride.Ring closures were achieved by heating 3 under alkaline or acidic conditions.Substitution of chlorine in 3a with aromatic amines provided 1-aryl-1,2-dihydro-2-imino-3,5-pyridinedicarbonitriles 7.Hydrolysis of 7 gave the 2-oxo-derivatives 8.